Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7420
Title: Paracetamol therapy for patent ductus arteriosus in premature i·nfants: A chance before surgical ligation
Authors: Özdemir, Özmert Muhammet Ali
Dogan, M.
Küçüktaşçi, K.
Ergin, Hacer
Şahin, O.
Keywords: Ibuprofen
Paracetamol
Patent ductus arteriosus
Premature
paracetamol
absence of side effects
article
birth weight
clinical article
follow up
gestational age
human
newborn
patent ductus arteriosus
prematurity
preoperative treatment
treatment outcome
Acetaminophen
Administration, Oral
Analgesics, Non-Narcotic
Cardiac Surgical Procedures
Dose-Response Relationship, Drug
Drug Administration Schedule
Ductus Arteriosus, Patent
Female
Follow-Up Studies
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases
Ligation
Male
Preoperative Care
Retrospective Studies
Treatment Outcome
Abstract: Patent ductus arteriosus (PDA) remains a common problem in premature infants. Treatment options include pharmacologic therapy and surgical ligation, but these are associated with potentially significant adverse effects. This report describes the effect of administering oral paracetamol to premature neonates with PDA. The study enrolled seven premature neonates followed up with the diagnosis of hemodynamically significant PDA (hsPDA) between February and December 2012 and treated with oral paracetamol. Patients with hsPDA were given at least two or more courses of ibuprofen treatment. If this therapy failed to promote ductal closure, the patients with clinical symptoms who had hsPDA defined by echocardiography were treated with oral paracetamol (15 mg/kg every 6 h). If these patients did not respond to paracetamol therapy, the PDA was closed by surgical ligation. The mean gestational age of the seven patients in this study was 26.1 weeks, and their mean birth weight was 936 g. Paracetamol treatment was started at 36.2 ± 11.6 days. The mean internal ductal diameter was 2.0 ± 0.2 mm, and the left atrium-to-aorta ratio was 1.5 ± 0.2. All the patients were administered oral paracetamol because of no response to ibuprofen treatment. The hsPDA was successfully closed with oral paracetamol in five (71.4 %) of the seven patients. The remaining two patients had surgical ligation performed, but one of them died. No side effects related to paracetamol were observed. Oral paracetamol may be used as an alternative drug for the management of hsPDA in premature neonates when ibuprofen treatment is unsuccessful and the only other therapeutic option is surgery. © 2013 Springer Science+Business Media New York.
URI: https://hdl.handle.net/11499/7420
https://doi.org/10.1007/s00246-013-0770-9
ISSN: 0172-0643
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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