Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7430
Title: Protective effect of esterified glucomannan on aflatoxin-induced changes in testicular function, sperm quality, and seminal plasma biochemistry in rams
Authors: Ataman, M.B.
Dönmez, H.H.
Dönmez, N.
Sur, E.
Bucak, M.N.
Çoyan, Kenan
Keywords: Aflatoxin
Glucomannan
Ram
Reproductive parameters
(1 6) alpha glucomannan
(1-6)-alpha-glucomannan
aflatoxin
glutathione
hyaluronoglucosaminidase
malonaldehyde
mannan
protective agent
acrosome
animal
animal food
article
drug effect
male
metabolism
physiology
RAM
reproductive parameters
sheep
sperm
spermatozoon motility
testis
ultrastructure
Acrosome
Aflatoxins
Animal Feed
Animals
Glutathione
Hyaluronoglucosaminidase
Male
Malondialdehyde
Mannans
Protective Agents
Semen
Sheep
Sperm Motility
Testis
Abstract: The aim of this study was to determine the effect of aflatoxin (AF) on spermatologic, biochemical, and testis parameters in rams, and the protective efficiency of esterified glucomannan (EG) co-administered with AF. Thirty-two Merino rams (12-14 months old) were used. The experimental design consisted of four dietary treatments. The control group was fed commercial feed. The AF group was fed with commercial feed plus 250 µg/d of total AF. The EG group received commercial feed plus 2 g/d of EG. The AF + EG group was given commercial feed plus 250 µg/d of total AF and 2 g/d of EG. There were treatment, time, and treatment-by-time interaction effects on sperm motility, abnormal spermatozoa, damaged acrosome, and dead spermatozoa (P < 0.01). The percentage of motile sperm was lower and the percentages of abnormal sperm, sperm with damaged acrosomes, and dead sperm were greater in the AF group than in the control, AF+EG, and EG groups, as from week 3 until the end of week 12 (P < 0.05). As from week 3, hyaluronidase activity in the seminal plasma increased significantly in the AF group, compared with the control. The co-administration of AF+EG was found to be effective in preventing the increase in hyaluronidase activity. As week 4, malondialdehyde (MDA) levels were significantly higher in the AF group compared with the control. The combined administration of AF+EG was found to be effective in lowering the MDA levels, increased by AF, to the levels measured in the control (P < 0.05). Although glutathione (GSH) levels were determined to have significantly decreased in the AF group in comparison to the control, it was observed that, in the group co-administered with AF and EG, particularly after week 7, the GSH levels, which had decreased owing to AF, were largely ameliorated (P < 0.05). In conclusion, AF adversely affected spermatologic, biochemical, and testis parameters, and the combined administration of EG with AF reversibly eliminated these adverse effects in rams. © 2014.
URI: https://hdl.handle.net/11499/7430
https://doi.org/10.1016/j.theriogenology.2013.10.007
ISSN: 0093-691X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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