Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7486
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dc.contributor.authorÇetin, Gökhan Ozan-
dc.contributor.authorCaner, Vildan-
dc.contributor.authorTürk, Nilay Şen-
dc.contributor.authorOkur, V.-
dc.contributor.authorCan, O.-
dc.contributor.authorEskicorapci, S.-
dc.contributor.authorTuncay, L.-
dc.date.accessioned2019-08-16T12:29:43Z-
dc.date.available2019-08-16T12:29:43Z-
dc.date.issued2014-
dc.identifier.issn1529-9120-
dc.identifier.urihttps://hdl.handle.net/11499/7486-
dc.description.abstractBladder cancer is the one of the most common cancers worldwide and O6-Methylguanine DNA Methyltransferase (MGMT) promoter methylation might be contributing to clinicopathological features of the disease. We analyzed formalin-fixed, paraffin-embedded bladder tissue samples from 101 patients with urothelial carcinoma. All samples were analyzed by real-time methylation-specific PCR. MGMT promoter methylation was detected in 15 (14.9%) of the samples and was not significantly different between any of the groups, although the number of high grade tumors with MGMT promoter methylation was twice the number of low grade tumors. Methylation of MGMT in high grade tumors might play a role in aggressive proliferation of the tumor cells and a poor prognosis.en_US
dc.language.isoenen_US
dc.publisherGene Therapy and Molecular Biologyen_US
dc.relation.ispartofGene Therapy and Molecular Biologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder canceren_US
dc.subjectMethylationen_US
dc.subjectO6-Methylguanine DNA methyltransferaseen_US
dc.subjectUrothelial carcinomaen_US
dc.subjectmethylated DNA protein cysteine methyltransferaseen_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectArticleen_US
dc.subjectbladder canceren_US
dc.subjectcancer gradingen_US
dc.subjectcancer incidenceen_US
dc.subjectcancer patienten_US
dc.subjectcancer prognosisen_US
dc.subjectcell proliferationen_US
dc.subjectclinical featureen_US
dc.subjectDNA methylationen_US
dc.subjectfemaleen_US
dc.subjecthistopathologyen_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectpromoter regionen_US
dc.subjectreal time polymerase chain reactionen_US
dc.subjecttissue fixationen_US
dc.subjecttransitional cell carcinomaen_US
dc.subjecttumor cellen_US
dc.titleCorrelation of O6-Methylguanine DNA methyltransferase promoter methylation and clinicopathological parameters in bladder canceren_US
dc.typeArticleen_US
dc.identifier.volume16en_US
dc.identifier.issue1en_US
dc.identifier.startpage181-
dc.identifier.startpage181en_US
dc.identifier.endpage189en_US
dc.authorid0000-0002-6100-7973-
dc.authorid0000-0003-0980-9335-
dc.authorid0000-0002-8294-558X-
dc.authorid0000-0003-4631-6337-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-84920690585en_US
dc.identifier.scopusqualityQ4-
dc.ownerPamukkale University-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.01. Surgical Medicine-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
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