Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/7519
Title: | Clinical and pathological features of lipoleiomyoma of the uterine corpus: A review of 76 cases | Authors: | Akbulut, Metin Gündoğan, Mehmet Yörükoğlu, Aygün |
Keywords: | Estrogen Gynecologic carcinoma Histogenesis Lipoleiomyoma desmin estrogen Ki 67 antigen progesterone protein S 100 vimentin adenomyosis adipose tissue adult aged Article clinical feature disease association endometriosis endometrium hyperplasia endometrium polyp female follow up gynecologic cancer histopathology human human tissue immunohistochemistry major clinical study medical record review retroperitoneal tumor uterine corpus uterine lipoleiomyoma uterus uterus myoma |
Publisher: | AVES Ibrahim Kara | Abstract: | Background: Uterine lipoleiomyoma is a rare and specific type of leiomyoma with a considerable amount of adipocytes. Aims: The aim of the study was to investigate the clinical, pathological and immunohistochemical features of lipoleiomyoma of the uterine corpus, and review its histogenesis and differential diagnosis from other neoplastic and non-neoplastic lesions in order to obtain a detailed profile of this somewhat uncommon lesion. Study Design: Descriptive study. Methods: This study is a retrospective analysis of 70 consecutive women with 76 lipoleiomyomas, who underwent surgery mainly for uterine leiomyoma and gynecological carcinomas between January 2000 and April 2013. Clinical and pathological information was obtained from medical records. Immunohistochemistry was applied in selected cases. Parametric methods were used to compare clinical and pathologic features. Results: The patients ranged in age from 34 to 77 years (mean 55.49 years). Lipoleiomyomas ranged from 0.5 to 55 cm in diameter (mean 5.50 cm). Typical macroscopic and microscopic features were noted. Sixty-nine (90.7%) tumors were in the uterine corpus and five (6.5%) were in the cervix. One broad ligament tumor and one retroperitoneal tumor were also studied. No tumors displayed cytologic atypia, mitosis, necrosis, calcification, or other degenerative changes. Immunohistochemically, the adipose tissue element was positive for vimentin, desmin, S100 protein, estrogen (ER), progesterone (PR), and Ki-67. Among patients with lipoleiomyomas, 53 cases (75.7%) had different types of lesions associated with hyperestrogenic status, such as adenomyosis, endometriosis, endometrial hyperplasia, and polyps, complex atypical endometrial hyperplasia, and gynecologic carcinomas. The follow-up period ranged from one to eight years (mean 4.6 years). There were no recurrences or tumor-related fatalities. Conclusion: In the present study, the lipoleiomyomas were seen more frequently in patients with adenomyosis, endometriosis, endometrial hyperplasia, polyps, and various gynecologic carcinomas. Lipoleiomyoma of the uterus seems to have a benign clinical course. © 2014, Trakya University Faculty of Medicine. |
URI: | https://hdl.handle.net/11499/7519 https://doi.org/10.5152/balkanmedj.2014.13079 |
ISSN: | 2146-3123 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
pdf_BMJ_289.pdf | 312.8 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
24
checked on Aug 17, 2024
WEB OF SCIENCETM
Citations
27
checked on Aug 9, 2024
Page view(s)
48
checked on Aug 24, 2024
Download(s)
12
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.