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https://hdl.handle.net/11499/7530
Title: | Effects of menopause, diabetes mellitus and steroid use on type I mesh-induced tissue reaction in a rat model | Authors: | Karabulut, A. Akyer, Şahika Pınar Abban Mete, Gülçin Şahin, Barbaros |
Keywords: | Diabetes mellitus Inflammation Menopause Mesh reaction Urogynecology methylprednisolone collagen steroid abdomen animal experiment animal model article biomechanics controlled study diabetes mellitus female foreign body reaction granulocyte histopathology implantation inflammation lymphocytic infiltration menopause necrosis nonhuman pelvis surgery plastic surgery priority journal rat rectus abdominis muscle steroid therapy strength surgical mesh tissue reaction type i polypropylene mesh vagina abdominal wall adverse effects animal complication experimental diabetes mellitus Foreign-Body Reaction materials testing ovariectomy severity of illness index surgery Wistar rat animal tissue Article cell infiltration fibroblast fibrosis mast cell polypropylene mesh tissue necrosis vaginal tissue Abdominal Wall Animals Diabetes Mellitus, Experimental Female Materials Testing Methylprednisolone Models, Animal Ovariectomy Rats Rats, Wistar Severity of Illness Index Surgical Mesh |
Publisher: | Elsevier Ireland Ltd | Abstract: | Objective: To evaluate the effects of menopause, use of steroids, diabetes mellitus, and site of implantation on the tissue response to type I polypropylene mesh used in pelvic reconstructive surgery. Study design: Forty mature female albino rats were used in the study. Inflammatory reaction and mesh-tissue detachment strength were studied in 4 different animal models; control (GI), menopause (GII), steroid + menopause (GIII), and diabetes mellitus + menopause (GIV) groups. Two pieces of 1 cm × 1 cm type I macro porous polypropylene monofilament mesh were fixed over rectus abdominis muscle on both sides of the midline, and 0.5 cm × 0.5 cm in size was placed into paravaginal area. Nine weeks later, implanted sling materials in the vaginal region and the right abdominal side were harvested with surrounding tissue for histopathologic examination, whereas the left sided meshes were used for the mechanical testing of detachment strength. Results: The mean detachment strengths in groups were, 595 ± 274 g for GI, 410 ± 161 g for GII, 610 ± 202 g for GIII, and 457 ± 250 g for GIV (p > 0.008). Inflammatory process was more intense in menopause and DM + menopause groups for both abdominal and vaginal tissues (p < 0.008). There was no difference between control and steroid + menopause groups, and DM + menopause and menopause groups (p > 0.008). Comparison of tissue reaction caused by meshes in abdominal and vaginal area showed more intense granulocyte infiltration in abdominal region whereas more prominent inflammation and necrosis in the vaginal site (p < 0.05). Conclusion: The abdominal and vaginal region show differences in tissue reaction to type I mesh, and menopause was the most determining factor on the intensity of mesh induced inflammatory response. © 2014 Elsevier Ireland Ltd. All rights reserved. | URI: | https://hdl.handle.net/11499/7530 https://doi.org/10.1016/j.ejogrb.2014.03.024 |
ISSN: | 0301-2115 |
Appears in Collections: | Acıpayam Meslek Yüksekokulu Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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