Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7530
Title: Effects of menopause, diabetes mellitus and steroid use on type I mesh-induced tissue reaction in a rat model
Authors: Karabulut, A.
Akyer, Şahika Pınar
Abban Mete, Gülçin
Şahin, Barbaros
Keywords: Diabetes mellitus
Inflammation
Menopause
Mesh reaction
Urogynecology
methylprednisolone
collagen
steroid
abdomen
animal experiment
animal model
article
biomechanics
controlled study
diabetes mellitus
female
foreign body reaction
granulocyte
histopathology
implantation
inflammation
lymphocytic infiltration
menopause
necrosis
nonhuman
pelvis surgery
plastic surgery
priority journal
rat
rectus abdominis muscle
steroid therapy
strength
surgical mesh
tissue reaction
type i polypropylene mesh
vagina
abdominal wall
adverse effects
animal
complication
experimental diabetes mellitus
Foreign-Body Reaction
materials testing
ovariectomy
severity of illness index
surgery
Wistar rat
animal tissue
Article
cell infiltration
fibroblast
fibrosis
mast cell
polypropylene mesh
tissue necrosis
vaginal tissue
Abdominal Wall
Animals
Diabetes Mellitus, Experimental
Female
Materials Testing
Methylprednisolone
Models, Animal
Ovariectomy
Rats
Rats, Wistar
Severity of Illness Index
Surgical Mesh
Publisher: Elsevier Ireland Ltd
Abstract: Objective: To evaluate the effects of menopause, use of steroids, diabetes mellitus, and site of implantation on the tissue response to type I polypropylene mesh used in pelvic reconstructive surgery. Study design: Forty mature female albino rats were used in the study. Inflammatory reaction and mesh-tissue detachment strength were studied in 4 different animal models; control (GI), menopause (GII), steroid + menopause (GIII), and diabetes mellitus + menopause (GIV) groups. Two pieces of 1 cm × 1 cm type I macro porous polypropylene monofilament mesh were fixed over rectus abdominis muscle on both sides of the midline, and 0.5 cm × 0.5 cm in size was placed into paravaginal area. Nine weeks later, implanted sling materials in the vaginal region and the right abdominal side were harvested with surrounding tissue for histopathologic examination, whereas the left sided meshes were used for the mechanical testing of detachment strength. Results: The mean detachment strengths in groups were, 595 ± 274 g for GI, 410 ± 161 g for GII, 610 ± 202 g for GIII, and 457 ± 250 g for GIV (p > 0.008). Inflammatory process was more intense in menopause and DM + menopause groups for both abdominal and vaginal tissues (p < 0.008). There was no difference between control and steroid + menopause groups, and DM + menopause and menopause groups (p > 0.008). Comparison of tissue reaction caused by meshes in abdominal and vaginal area showed more intense granulocyte infiltration in abdominal region whereas more prominent inflammation and necrosis in the vaginal site (p < 0.05). Conclusion: The abdominal and vaginal region show differences in tissue reaction to type I mesh, and menopause was the most determining factor on the intensity of mesh induced inflammatory response. © 2014 Elsevier Ireland Ltd. All rights reserved.
URI: https://hdl.handle.net/11499/7530
https://doi.org/10.1016/j.ejogrb.2014.03.024
ISSN: 0301-2115
Appears in Collections:Acıpayam Meslek Yüksekokulu Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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