Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7543
Title: Adipocytokine concentrations in children with different types of beta-thalassemia
Authors: Enli, Yaşar
Balci, Y.I.
Gönen, C.
Uzun, Ebru
Polat, A.
Keywords: Adipocytokine
Adiponectin
Beta-thalassemia
Resistin
Visfatin
adiponectin
hemoglobin
nicotinamide phosphoribosyltransferase
resistin
ADIPOQ protein, human
cytokine
nicotinamide phosphoribosyltransferase, human
RETN protein, human
anthropometry
article
beta thalassemia
blood transfusion
child
childhood disease
controlled study
correlational study
disease severity
erythrocyte count
female
hematocrit
hemoglobin blood level
human
major clinical study
male
priority journal
thalassemia intermedia
thalassemia major
thalassemia minor
adolescent
beta-Thalassemia
blood
case control study
preschool child
Adolescent
Case-Control Studies
Child
Child, Preschool
Cytokines
Humans
Male
Nicotinamide Phosphoribosyltransferase
Publisher: Informa Healthcare
Abstract: Background. Beta-thalassemia is an inherited blood disorder. It results from the impaired production of ß-globin chains, leading to a relative excess of alpha-globin chains. Clinical severity separates this disease into three main subtypes: ß- thalassemia major, ß-thalassemia intermedia and ß-thalassemia minor, the former two being clinically more significant. Inflammatory processes may play an important role in some of the complications of thalassemia. Adipose tissue is one of the most important endocrine and secretory organs that release adipocytokines like adiponectin, resistin and visfatin. Aim. The aim of our study was to analyze adipocytokine concentrations (adiponectin, resistin and visfatin) in different types of ß-thalassemia patients and determine any possible correlations with disease severity. Methods. We recruited 29 patients who were transfusion-dependent ß-thalassemia- major patients, 17 patients with ß-thalassemia intermedia, 30 ß-thalassemia minor patients. The control group consisted of 30 healthy children. Anthropometric measurements, complete blood count, biochemical parameters, serum concentrations of adiponectin, resistin, visfatin were performed for all subjects. Results. Resistin and visfatin concentrations were significantly higher in ß-thalassemia minor patients than in controls. Adiponectin, resistin and visfatin concentrations were significantly higher in both ß-thalassemia intermedia and major patients than in controls. The concentrations of adiponectin, resistin and visfatin were significantly higher in both ß-thalassemia intermedia and major patients than in ß-thalassemia minor patients. There was no significant difference between ß-thalassemia intermedia and ß-thalassemia major patients for adipocytokines concentrations. Conclusion. We speculate that these adipocytokines may play a role in the development of complications in ß-thalassaemia. © 2014 Informa Healthcare.
URI: https://hdl.handle.net/11499/7543
https://doi.org/10.3109/00365513.2014.883639
ISSN: 0036-5513
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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