Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/7543
Title: | Adipocytokine concentrations in children with different types of beta-thalassemia | Authors: | Enli, Yaşar Balci, Y.I. Gönen, C. Uzun, Ebru Polat, A. |
Keywords: | Adipocytokine Adiponectin Beta-thalassemia Resistin Visfatin adiponectin hemoglobin nicotinamide phosphoribosyltransferase resistin ADIPOQ protein, human cytokine nicotinamide phosphoribosyltransferase, human RETN protein, human anthropometry article beta thalassemia blood transfusion child childhood disease controlled study correlational study disease severity erythrocyte count female hematocrit hemoglobin blood level human major clinical study male priority journal thalassemia intermedia thalassemia major thalassemia minor adolescent beta-Thalassemia blood case control study preschool child Adolescent Case-Control Studies Child Child, Preschool Cytokines Humans Male Nicotinamide Phosphoribosyltransferase |
Publisher: | Informa Healthcare | Abstract: | Background. Beta-thalassemia is an inherited blood disorder. It results from the impaired production of ß-globin chains, leading to a relative excess of alpha-globin chains. Clinical severity separates this disease into three main subtypes: ß- thalassemia major, ß-thalassemia intermedia and ß-thalassemia minor, the former two being clinically more significant. Inflammatory processes may play an important role in some of the complications of thalassemia. Adipose tissue is one of the most important endocrine and secretory organs that release adipocytokines like adiponectin, resistin and visfatin. Aim. The aim of our study was to analyze adipocytokine concentrations (adiponectin, resistin and visfatin) in different types of ß-thalassemia patients and determine any possible correlations with disease severity. Methods. We recruited 29 patients who were transfusion-dependent ß-thalassemia- major patients, 17 patients with ß-thalassemia intermedia, 30 ß-thalassemia minor patients. The control group consisted of 30 healthy children. Anthropometric measurements, complete blood count, biochemical parameters, serum concentrations of adiponectin, resistin, visfatin were performed for all subjects. Results. Resistin and visfatin concentrations were significantly higher in ß-thalassemia minor patients than in controls. Adiponectin, resistin and visfatin concentrations were significantly higher in both ß-thalassemia intermedia and major patients than in controls. The concentrations of adiponectin, resistin and visfatin were significantly higher in both ß-thalassemia intermedia and major patients than in ß-thalassemia minor patients. There was no significant difference between ß-thalassemia intermedia and ß-thalassemia major patients for adipocytokines concentrations. Conclusion. We speculate that these adipocytokines may play a role in the development of complications in ß-thalassaemia. © 2014 Informa Healthcare. | URI: | https://hdl.handle.net/11499/7543 https://doi.org/10.3109/00365513.2014.883639 |
ISSN: | 0036-5513 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
SCOPUSTM
Citations
9
checked on Feb 24, 2024
WEB OF SCIENCETM
Citations
9
checked on Sep 30, 2024
Page view(s)
90
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.