Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7572
Title: Immunohistochemical investigation of galectin-3 in the skin of mice applied with Origanum hypericifolium essential oil and irradiated with ultraviolet B
Authors: İli, Pınar
Keskin, Nazan
Keywords: Galectin-3
Origanum hypericifolium
Skin
UVB
essential oil
galectin 3
Origanum hypericifolium essential oil
unclassified drug
origanum oil
animal tissue
article
controlled study
dermatitis
female
immunocompetent cell
immunohistochemistry
immunoreactivity
immunosuppressive treatment
medicinal plant
mouse
nonhuman
skin
ultraviolet B radiation
animal
Bagg albino mouse
chemistry
drug effects
metabolism
Origanum
radiation response
ultraviolet radiation
Animals
Female
Galectin 3
Immunohistochemistry
Mice
Mice, Inbred BALB C
Oils, Volatile
Ultraviolet Rays
Publisher: Turkiye Klinikleri Journal of Medical Sciences
Abstract: Aim: To demonstrate galectin-3-immunoreactivity in the undiluted essential oil of Origanum hypericifolium when applied to the ultraviolet B (UVB) irradiated skin of mice. Materials and methods: Female BALB/c mice were allocated to 4 groups, each comprising 6 mice (Group 1: control; Group 2: UVB irradiated control; Group 3: undiluted O. hypericifolium essential oil applied; Group 4: undiluted O. hypericifolium essential oil applied before UVB irradiation). One week prior to UVB irradiation, the undiluted O. hypericifolium essential oil was applied to the shaved dorsal skin of mice 3 times a week. Subsequently, the mice were irradiated 3 times per week with UVB (week 1: 50 mJ/cm2, week 2: 70 mJ/cm2, and weeks 3 and 4: 80 mJ/cm2) for 4 weeks. At the end of this period, immunohistochemical staining for galectin-3 was performed on frozen sections of skin specimens, and then they were photographed. Results: Numerous galectin-3-immunoreactive cells, which were considered to be immune system cells, were observed in the dermis of Group 3. Conclusion: It is suggested that undiluted O. hypericifolium essential oil may cause an increase in the galectin-3-immunoreactive cells. However, there is a need to research these findings with further molecular analyses. © TÜBİTAK.
URI: https://hdl.handle.net/11499/7572
https://doi.org/10.3906/sag-1304-9
ISSN: 1300-0144
Appears in Collections:Fen-Edebiyat Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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