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https://hdl.handle.net/11499/7572
Title: | Immunohistochemical investigation of galectin-3 in the skin of mice applied with Origanum hypericifolium essential oil and irradiated with ultraviolet B | Authors: | İli, Pınar Keskin, Nazan |
Keywords: | Galectin-3 Origanum hypericifolium Skin UVB essential oil galectin 3 Origanum hypericifolium essential oil unclassified drug origanum oil animal tissue article controlled study dermatitis female immunocompetent cell immunohistochemistry immunoreactivity immunosuppressive treatment medicinal plant mouse nonhuman skin ultraviolet B radiation animal Bagg albino mouse chemistry drug effects metabolism Origanum radiation response ultraviolet radiation Animals Female Galectin 3 Immunohistochemistry Mice Mice, Inbred BALB C Oils, Volatile Ultraviolet Rays |
Publisher: | Turkiye Klinikleri Journal of Medical Sciences | Abstract: | Aim: To demonstrate galectin-3-immunoreactivity in the undiluted essential oil of Origanum hypericifolium when applied to the ultraviolet B (UVB) irradiated skin of mice. Materials and methods: Female BALB/c mice were allocated to 4 groups, each comprising 6 mice (Group 1: control; Group 2: UVB irradiated control; Group 3: undiluted O. hypericifolium essential oil applied; Group 4: undiluted O. hypericifolium essential oil applied before UVB irradiation). One week prior to UVB irradiation, the undiluted O. hypericifolium essential oil was applied to the shaved dorsal skin of mice 3 times a week. Subsequently, the mice were irradiated 3 times per week with UVB (week 1: 50 mJ/cm2, week 2: 70 mJ/cm2, and weeks 3 and 4: 80 mJ/cm2) for 4 weeks. At the end of this period, immunohistochemical staining for galectin-3 was performed on frozen sections of skin specimens, and then they were photographed. Results: Numerous galectin-3-immunoreactive cells, which were considered to be immune system cells, were observed in the dermis of Group 3. Conclusion: It is suggested that undiluted O. hypericifolium essential oil may cause an increase in the galectin-3-immunoreactive cells. However, there is a need to research these findings with further molecular analyses. © TÜBİTAK. | URI: | https://hdl.handle.net/11499/7572 https://doi.org/10.3906/sag-1304-9 |
ISSN: | 1300-0144 |
Appears in Collections: | Fen-Edebiyat Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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sag-44-3-12-1304-9.pdf | 1.21 MB | Adobe PDF | View/Open |
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