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https://hdl.handle.net/11499/7607
Title: | The effect of using different embolic agents on survival in transarterial chemoembolization of hepatocellular carcinoma: Gelfoam versus polyvinyl alcohol | Authors: | Koçyigit, Ali Dicle, O. Göktay, Y. Astarcioglu, I. |
Keywords: | alpha fetoprotein doxorubicin gelfoam gelitaspon iodinated poppyseed oil iopromide polyvinyl alcohol unclassified drug gelatin sponge adult age alpha fetoprotein blood level ascites brain disease chemoembolization clinical article female follow up human liver cell carcinoma male moderate hepatic impairment multidetector computed tomography overall survival peritonitis pleura effusion postembolectomy syndrome postoperative complication retrospective study review treatment response Carcinoma, Hepatocellular comparative study Kaplan Meier method Liver Neoplasms middle aged procedures survival rate treatment outcome Chemoembolization, Therapeutic Female Gelatin Sponge, Absorbable Humans Kaplan-Meier Estimate Male Middle Aged Polyvinyl Alcohol Retrospective Studies Survival Rate Treatment Outcome |
Publisher: | AVES Ibrahim Kara | Abstract: | PURPOSE We aimed to compare the effect of using different embolic agents such as gelfoam and polyvinyl alcohol (PVA) on survival, tumor response, and complications in transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) patients. MATERIALS AND METHODS We retrospectively reviewed the medical records of 38 inoperable HCC patients who underwent TACE between August 1998 and April 2007. A total of 50 TACE sessions were performed using PVA (n=18) or gelfoam particles (n=20), following the application of 60 mg doxorubicin with 10-20 mL lipiodol emulsion. The PVA and gelfoam groups were compared based on clinical, laboratory, and demographic variables. Survival rates were calculated starting from the first TACE session using the Kaplan-Meier analysis. RESULTS There was no significant difference between the survival rates of PVA and gelfoam groups (P = 0.235). Overall survival rates at 12, 24, 36, 48, and 60 months were 55%, 36%, 15%, 7%, and 5%, respectively. Tumor response, age, lipiodol accumulation type, number of HCC foci, complications, and serum alpha-fetoprotein level were significant factors for survival in all patients. CONCLUSION Use of gelfoam or PVA as the embolic agent did not have a significant impact on survival. Complete tumor response, intensive lipiodol accumulation in tumor, older age (>60 years), fewer (?3) HCC foci, and low serum alpha-fetoprotein level (?400 ng/mL) were found to improve cumulative survival significantly. © Turkish Society of Radiology 2014. | URI: | https://hdl.handle.net/11499/7607 https://doi.org/10.5152/dir.2014.13462 |
ISSN: | 1305-3825 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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