Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7607
Title: The effect of using different embolic agents on survival in transarterial chemoembolization of hepatocellular carcinoma: Gelfoam versus polyvinyl alcohol
Authors: Koçyigit, Ali
Dicle, O.
Göktay, Y.
Astarcioglu, I.
Keywords: alpha fetoprotein
doxorubicin
gelfoam
gelitaspon
iodinated poppyseed oil
iopromide
polyvinyl alcohol
unclassified drug
gelatin sponge
adult
age
alpha fetoprotein blood level
ascites
brain disease
chemoembolization
clinical article
female
follow up
human
liver cell carcinoma
male
moderate hepatic impairment
multidetector computed tomography
overall survival
peritonitis
pleura effusion
postembolectomy syndrome
postoperative complication
retrospective study
review
treatment response
Carcinoma, Hepatocellular
comparative study
Kaplan Meier method
Liver Neoplasms
middle aged
procedures
survival rate
treatment outcome
Chemoembolization, Therapeutic
Female
Gelatin Sponge, Absorbable
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Polyvinyl Alcohol
Retrospective Studies
Survival Rate
Treatment Outcome
Publisher: AVES Ibrahim Kara
Abstract: PURPOSE We aimed to compare the effect of using different embolic agents such as gelfoam and polyvinyl alcohol (PVA) on survival, tumor response, and complications in transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) patients. MATERIALS AND METHODS We retrospectively reviewed the medical records of 38 inoperable HCC patients who underwent TACE between August 1998 and April 2007. A total of 50 TACE sessions were performed using PVA (n=18) or gelfoam particles (n=20), following the application of 60 mg doxorubicin with 10-20 mL lipiodol emulsion. The PVA and gelfoam groups were compared based on clinical, laboratory, and demographic variables. Survival rates were calculated starting from the first TACE session using the Kaplan-Meier analysis. RESULTS There was no significant difference between the survival rates of PVA and gelfoam groups (P = 0.235). Overall survival rates at 12, 24, 36, 48, and 60 months were 55%, 36%, 15%, 7%, and 5%, respectively. Tumor response, age, lipiodol accumulation type, number of HCC foci, complications, and serum alpha-fetoprotein level were significant factors for survival in all patients. CONCLUSION Use of gelfoam or PVA as the embolic agent did not have a significant impact on survival. Complete tumor response, intensive lipiodol accumulation in tumor, older age (>60 years), fewer (?3) HCC foci, and low serum alpha-fetoprotein level (?400 ng/mL) were found to improve cumulative survival significantly. © Turkish Society of Radiology 2014.
URI: https://hdl.handle.net/11499/7607
https://doi.org/10.5152/dir.2014.13462
ISSN: 1305-3825
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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