Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7610
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dc.contributor.authorKiter, Esat-
dc.contributor.authorEr, Ertan-
dc.contributor.authorŞen Türk, N.-
dc.contributor.authorOto, Murat-
dc.contributor.authorAkkaya, Semih-
dc.date.accessioned2019-08-16T12:30:46Z-
dc.date.available2019-08-16T12:30:46Z-
dc.date.issued2014-
dc.identifier.issn1017-995X-
dc.identifier.urihttps://hdl.handle.net/11499/7610-
dc.identifier.urihttps://doi.org/10.3944/AOTT.2014.3161-
dc.description.abstractObjective: The aim of this study was to investigate the influence of the antiproliferative agent 5-Fluorouracil (5FU) over inhibition of spinal bone formation in an experimental rat model. Methods: The study included 30 6-month-old Sprague-Dawley rats divided into 3 groups. Aggressive periosteal denuding was performed by scalpel to induce punctuate bleeding in the posterior elements of the L4-L5 vertebrae in the spontaneous fusion model. Spinous processes were fixated by wires and no graft substitute was applied. Adcon-L was applied in Group 1, single-touch technique 5FU in Group 2. Group 3 was the control group. Rats were sacrificed at 4 weeks and specimens acquired for histological examination. Results: 5FU substantially inhibited fibroblast and inflammatory cell densities as well as bone formation compared to the control group. 5FU was considerably superior to Adcon-L with regard to inhibition of bone formation and inflammatory cells (p=0.0001). Conclusion: 5FU can inhibit fusion, fibrosis and unwanted scar tissue in spinal surgery. We believe that after further studies on its local delivery dose, it can be used in humans for inhibition of unintended fusion. © 2014 Turkish Association of Orthopaedics and Traumatology.en_US
dc.language.isoenen_US
dc.publisherEkin Medical Publishingen_US
dc.relation.ispartofActa Orthopaedica et Traumatologica Turcicaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject5-Fluorouracilen_US
dc.subjectInhibition of spinal fusionen_US
dc.subjectSpontaneous spinal fusionen_US
dc.subjectADCON Len_US
dc.subjectADCON-Len_US
dc.subjectantimetaboliteen_US
dc.subjectfluorouracilen_US
dc.subjectorganic compounden_US
dc.subjectanimalen_US
dc.subjectarticleen_US
dc.subjectbone developmenten_US
dc.subjectdisease modelen_US
dc.subjectdrug effecten_US
dc.subjectraten_US
dc.subjectspine fusionen_US
dc.subjectSprague Dawley raten_US
dc.subjectAnimalsen_US
dc.subjectAntimetabolitesen_US
dc.subjectDisease Models, Animalen_US
dc.subjectFluorouracilen_US
dc.subjectOrganic Chemicalsen_US
dc.subjectOsteogenesisen_US
dc.subjectRatsen_US
dc.subjectRats, Sprague-Dawleyen_US
dc.subjectSpinal Fusionen_US
dc.titleEfficacy of 5-Fluorouracil in inhibition of unintended bone formation in spinal surgery: A histological evaluation on a rat model of spontaneous spinal fusionen_US
dc.typeArticleen_US
dc.identifier.volume48en_US
dc.identifier.issue1en_US
dc.identifier.startpage86-
dc.identifier.startpage86en_US
dc.identifier.endpage91en_US
dc.identifier.doi10.3944/AOTT.2014.3161-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid24643106en_US
dc.identifier.scopus2-s2.0-84896485429en_US
dc.identifier.wosWOS:000335199600015en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.01. Surgical Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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