Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/7610
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kiter, Esat | - |
dc.contributor.author | Er, Ertan | - |
dc.contributor.author | Şen Türk, N. | - |
dc.contributor.author | Oto, Murat | - |
dc.contributor.author | Akkaya, Semih | - |
dc.date.accessioned | 2019-08-16T12:30:46Z | - |
dc.date.available | 2019-08-16T12:30:46Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1017-995X | - |
dc.identifier.uri | https://hdl.handle.net/11499/7610 | - |
dc.identifier.uri | https://doi.org/10.3944/AOTT.2014.3161 | - |
dc.description.abstract | Objective: The aim of this study was to investigate the influence of the antiproliferative agent 5-Fluorouracil (5FU) over inhibition of spinal bone formation in an experimental rat model. Methods: The study included 30 6-month-old Sprague-Dawley rats divided into 3 groups. Aggressive periosteal denuding was performed by scalpel to induce punctuate bleeding in the posterior elements of the L4-L5 vertebrae in the spontaneous fusion model. Spinous processes were fixated by wires and no graft substitute was applied. Adcon-L was applied in Group 1, single-touch technique 5FU in Group 2. Group 3 was the control group. Rats were sacrificed at 4 weeks and specimens acquired for histological examination. Results: 5FU substantially inhibited fibroblast and inflammatory cell densities as well as bone formation compared to the control group. 5FU was considerably superior to Adcon-L with regard to inhibition of bone formation and inflammatory cells (p=0.0001). Conclusion: 5FU can inhibit fusion, fibrosis and unwanted scar tissue in spinal surgery. We believe that after further studies on its local delivery dose, it can be used in humans for inhibition of unintended fusion. © 2014 Turkish Association of Orthopaedics and Traumatology. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Ekin Medical Publishing | en_US |
dc.relation.ispartof | Acta Orthopaedica et Traumatologica Turcica | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | 5-Fluorouracil | en_US |
dc.subject | Inhibition of spinal fusion | en_US |
dc.subject | Spontaneous spinal fusion | en_US |
dc.subject | ADCON L | en_US |
dc.subject | ADCON-L | en_US |
dc.subject | antimetabolite | en_US |
dc.subject | fluorouracil | en_US |
dc.subject | organic compound | en_US |
dc.subject | animal | en_US |
dc.subject | article | en_US |
dc.subject | bone development | en_US |
dc.subject | disease model | en_US |
dc.subject | drug effect | en_US |
dc.subject | rat | en_US |
dc.subject | spine fusion | en_US |
dc.subject | Sprague Dawley rat | en_US |
dc.subject | Animals | en_US |
dc.subject | Antimetabolites | en_US |
dc.subject | Disease Models, Animal | en_US |
dc.subject | Fluorouracil | en_US |
dc.subject | Organic Chemicals | en_US |
dc.subject | Osteogenesis | en_US |
dc.subject | Rats | en_US |
dc.subject | Rats, Sprague-Dawley | en_US |
dc.subject | Spinal Fusion | en_US |
dc.title | Efficacy of 5-Fluorouracil in inhibition of unintended bone formation in spinal surgery: A histological evaluation on a rat model of spontaneous spinal fusion | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 86 | - |
dc.identifier.startpage | 86 | en_US |
dc.identifier.endpage | 91 | en_US |
dc.identifier.doi | 10.3944/AOTT.2014.3161 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 24643106 | en_US |
dc.identifier.scopus | 2-s2.0-84896485429 | en_US |
dc.identifier.wos | WOS:000335199600015 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
400-4054.pdf | 1.18 MB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
5
checked on Oct 13, 2024
WEB OF SCIENCETM
Citations
1
checked on Oct 31, 2024
Page view(s)
54
checked on Aug 24, 2024
Download(s)
16
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.