Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7751
Title: Smoking and sickle cell diseases
Authors: Helvaci, M.R.
Sevinc, A.
Camci, C.
Keskin, A.
Keywords: Atherosclerosis
Autosplenectomy
Sickle cell diseases
Smoking
article
atherosclerosis
autosplenectomy
chronic kidney disease
clinical assessment
controlled study
digital clubbing
erythrocyte transfusion
female
hematocrit
human
ischemic heart disease
leg ulcer
leukocyte count
major clinical study
male
prevalence
pulmonary hypertension
rheumatic heart disease
sickle cell anemia
smoking
spleen disease
thalassemia minor
thrombocyte count
Publisher: Cardiology Academic Press
Abstract: Background: We tried to understand whether or not there is an association between higher prevalence of smoking and autosplenectomy in sickle cell diseases (SCDs) cases. Methods: All SCDs patients with and without autosplenectomy were studied, and they were compared in between. Results: The study included 253 patients (124 females). There were 168 cases (66.4%) with autosplenectomy and 85 cases (33.5%) without (p<0.001). Autosplenectomy cases were significantly elder than the others (30.7 versus 25.7 years, p= 0.000). Female ratios were similar in both groups (p>0.05). Thalassemia minors were significantly higher in cases without autosplenectomy (91.7% versus 50.0%, p<0.001). Interestingly, prevalence of smoking was significantly higher in cases with autosplenectomy (16.6% versus 9.4%, p<0.05). The mean units of transfused red blood cells (RBCs) and painful crises per year were similar in both groups (p>0.05 for both). Both the white blood cell and platelet counts of the peripheric blood were higher in cases with autosplenectomy, significantly (p = 0.000 for both), whereas the mean hematocrit value was significantly lower in them (p= 0.000). On the other hand, prevalences of digital clubbing, pulmonary hypertension, leg ulcers, chronic renal disease, coronary heart disease, and rheumatic heart disease were significantly higher in cases with autosplenectomy (p<0.05 for all). Conclusion: Due to the strong atherosclerotic background of smoking and SCDs, there may be an association between higher prevalence of smoking and clinical severity of the SCDs, and the spleen, as a filter of blood for the abnormally hard RBCs, may strongly be affected in smoker patients with SCDs.
URI: https://hdl.handle.net/11499/7751
ISSN: 1205-6626
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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