Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7754
Title: Heart rate recovery after exercise and its relation with neutrophil-to-lymphocyte ratio in patients with cardiac syndrome X
Authors: Yurtdaş, M.
Yaylalı, Yalın Tolga
Aladag, N.
Özdemir, M.
Ceylan, Y.
Gençaslan, M.
Akbulut, T.
Keywords: C reactive protein
biological marker
adult
article
blood cell count
cardiac patient
cardiovascular parameters
cardiovascular risk
controlled study
coronary artery disease
duke treadmill score
exercise recovery
exercise test
female
heart rate
heart rate recovery
hematological parameters
high risk patient
human
major clinical study
male
middle aged
neutrophil to lymphocyte ratio
platelet to lymphocyte ratio
predictive value
priority journal
scoring system
syndrome X
treadmill exercise
angiocardiography
autonomic nervous system
blood
chi square distribution
comparative study
convalescence
exercise
lymphocyte
lymphocyte count
metabolism
Microvascular Angina
neutrophil
pathophysiology
prospective study
risk
risk factor
statistical model
time
Adult
Autonomic Nervous System
Biological Markers
C-Reactive Protein
Chi-Square Distribution
Coronary Angiography
Coronary Artery Disease
Exercise
Exercise Test
Heart Rate
Humans
Logistic Models
Lymphocyte Count
Lymphocytes
Middle Aged
Neutrophils
Odds Ratio
Predictive Value of Tests
Prospective Studies
Recovery of Function
Risk Factors
Time Factors
Publisher: Lippincott Williams and Wilkins
Abstract: OBJECTIVES: The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) are measures of systemic inflammation. Heart rate recovery (HRR) after exercise is influenced by autonomic function. The aim of this study was to ascertain whether HRR and the Duke Treadmill Score (DTS) values are related to NLR and PLR in patients with cardiac syndrome X (CSX). METHODS: A total of 350 participants were enrolled in the study. Complete blood counts and high-sensitivity C-reactive protein (hsCRP) were obtained. All participants underwent an exercise test. HRR and DTS were calculated after exercise. Abnormal HRR was defined as 12 beats/min or less. RESULTS: CSX and coronary artery disease (CAD) groups had higher NLR, PLR, and hsCRP, and lower HRR and DTS values than the control group (for all, P<0.05). In both CSX and CAD groups, HRR was positively correlated with DTS (r=0.468, P<0.001 and r=0.491, P<0.001, respectively) and negatively correlated with NLR (r=-0.519, P<0.001 and r=-0.612, P<0.001, respectively), PLR (r=-0.422, P<0.001 and r=-0.438, P<0.001, respectively), and hsCRP (r=-0.553, P<0.001 and r=-0.521, P<0.001, respectively). NLR and hsCRP were important two predictors of the presence of lower HRR in both CSX [NLR: odds ratio (OR), 0.395; 95% confidence interval (CI), 0.168-0.925; P=0.032 and hsCRP: OR, 0.748; 95% CI, 0.591-0.945; P=0.015], and CAD groups (NLR: OR, 0.115; 95% CI, 0.026-0.501; P=0.004 and hsCRP: OR, 0.637; 95% CI, 0.455-0.892; P=0.009). CONCLUSION: CSX patients have higher NLR and PLR and slower HRR and lower DTS, similar to CAD patients, suggesting that CSX patients may be at a higher risk for developing cardiovascular events in the future. NLR may predict autonomic imbalance assessed by HRR in CSX.
URI: https://hdl.handle.net/11499/7754
https://doi.org/10.1097/MCA.0000000000000110
ISSN: 0954-6928
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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