Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7777
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dc.contributor.authorToprak, İbrahim-
dc.contributor.authorKucukatay, V.-
dc.contributor.authorYildirim, C.-
dc.contributor.authorKılıç-Toprak, Emine-
dc.contributor.authorKilic-Erkek, O.-
dc.date.accessioned2019-08-16T12:32:00Z
dc.date.available2019-08-16T12:32:00Z
dc.date.issued2014-
dc.identifier.issn0950-222X-
dc.identifier.urihttps://hdl.handle.net/11499/7777-
dc.identifier.urihttps://doi.org/10.1038/eye.2013.262-
dc.description.abstractPurposeTo establish the effect of systemic oxidative stress on the pathogenesis of keratoconus by measuring serum total oxidant status (TOS) and total antioxidant status (TAS) in patients with keratoconus.MethodsTwenty-five patients with keratoconus (keratoconus group) and 25 age-sex-matched healthy subjects (control group) were enrolled in the study. Exclusion criteria were smoking habit, history of any other corneal pathology, systemic disease or inflammation, and current antioxidant or anti-inflammatory therapies. All participants underwent a detailed ophthalmological examination and corneal topography. Serum samples were obtained from all participants. Oxidative stress markers (TAS and TOS) were measured using a commercial kit and oxidative stress index (OSI) was calculated.ResultsThe study comprised 25 patients with keratoconus (mean age of 26.4±1.7 years) and 25 healthy control subjects (mean age of 26.6±1.7 years) (P>0.05). The serum TOS and OSI values were significantly higher in patients with keratoconus compared with those of the controls (P=0.036 and 0.037, respectively). However, serum TAS did not show significant difference between the keratoconus and control groups (P=0.497).ConclusionsThe higher levels of serum oxidant status and OSI in patients with keratoconus suggest that systemic oxidative stress might be involved in the pathogenesis of keratoconus. © 2014 Macmillan Publishers Limited.en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofEye (Basingstoke)en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant statusen_US
dc.subjectKeratoconusen_US
dc.subjectOxidant statusen_US
dc.subjectOxidative stressen_US
dc.subjectantioxidanten_US
dc.subjectoxidizing agenten_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectdisease severityen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectkeratoconusen_US
dc.subjectkeratometryen_US
dc.subjectmaleen_US
dc.subjectnamed inventories, questionnaires and rating scalesen_US
dc.subjectophthalmoscopyen_US
dc.subjectoxidative stressen_US
dc.subjectoxidative stress indexen_US
dc.subjectpathogenesisen_US
dc.subjectslit lampen_US
dc.subjecttonometryen_US
dc.subjectvisual acuity charten_US
dc.titleIncreased systemic oxidative stress in patients with keratoconusen_US
dc.typeArticleen_US
dc.identifier.volume28en_US
dc.identifier.issue3en_US
dc.identifier.startpage285
dc.identifier.startpage285en_US
dc.identifier.endpage289en_US
dc.authorid0000-0002-8795-0185-
dc.identifier.doi10.1038/eye.2013.262-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid24310241en_US
dc.identifier.scopus2-s2.0-84896371895en_US
dc.identifier.wosWOS:000332939400007en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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