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https://hdl.handle.net/11499/7797
Title: | Neutrophil-to-lymphocyte ratio may predict subclinical atherosclerosis in patients with psoriasis | Authors: | Yurtdaş, M. Yaylalı, Yalın Tolga Kaya, Y. Özdemir, M. Özkan, I. Alada?, N. |
Keywords: | Atherosclerosis Inflammation Intima-media thickness Propagation velocity Psoriasis C reactive protein adult aorta flow Article atherosclerosis blood cell count carotid artery controlled study female human leukocyte lymphocyte major clinical study male monocyte neutrophil neutrophil lymphocyte ratio platelet lymphocyte ratio psoriasis Psoriasis Area and Severity Index thrombocyte aorta arterial pressure arterial wall thickness blood complication echography heart ventricle middle aged procedures prospective study randomized controlled trial reproducibility risk assessment severity of illness index statistics and numerical data young adult Adult Aorta Arterial Pressure C-Reactive Protein Carotid Intima-Media Thickness Female Heart Ventricles Humans Lymphocytes Male Middle Aged Neutrophils Prospective Studies Reproducibility of Results Risk Assessment Severity of Illness Index Young Adult |
Publisher: | Blackwell Publishing Inc. | Abstract: | Background: Systemic inflammation beyond the skin may provide an explanation of the increased cardiovascular risk observed in psoriasis. It was hypothesized that neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are potential predictors of subclinical atherosclerosis measured by aortic velocity propagation (AVP) and carotid intima-media thickness (CIMT) in psoriasis. Methods: Fifty-one patients with psoriasis taking no antipsoriatic therapy and 37 age- and sex-matched healthy controls were prospectively enrolled. The Psoriasis Area and Severity Index (PASI) was calculated. Complete blood counts were obtained. Measurements of AVP and CIMT were performed. Results: The baseline clinical and demographic features, and white blood cell, platelet, neutrophil, lymphocyte, monocyte, and PLR were similar in both groups. NLR and high-sensitivity C-reactive protein (hs-CRP) were higher in the psoriasis group than the control group (P = 0.001, P < 0.001; respectively). The psoriasis group had lower AVP and higher CIMT values than those of controls (AVP: 48.9 ± 18.1 vs. 64.3 ± 14.5 cm/sec; P < 0.001, CIMT: 0.84 ± 0.29 vs. 0.63 ± 0.27 mm; P = 0.001, respectively). PASI was positively correlated with NLR and hs-CRP (r = 0.423, P = 0.002; r = 0.315, P = 0.024, respectively). There was an inverse association between AVP and CIMT (r = -0.749, P < 0.001). Binary logistic regression analysis demonstrated that NLR was the only variable able to predict lower AVP (?41 cm/sec) and higher CIMT (>0.9 mm) values (P = 0.024 and 0.023; respectively). Conclusion: NLR is potentially an unrecognized predictor of subclinical atherosclerosis in patients with psoriasis. Future studies assessing the prognostic significance of NLR on cardiovascular event rates in psoriasis patients would be of great interest. (Echocardiography 2014;31:1095-1104). © 2014, Wiley Periodicals, Inc. | URI: | https://hdl.handle.net/11499/7797 https://doi.org/10.1111/echo.12511 |
ISSN: | 0742-2822 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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