Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7797
Title: Neutrophil-to-lymphocyte ratio may predict subclinical atherosclerosis in patients with psoriasis
Authors: Yurtdaş, M.
Yaylalı, Yalın Tolga
Kaya, Y.
Özdemir, M.
Özkan, I.
Alada?, N.
Keywords: Atherosclerosis
Inflammation
Intima-media thickness
Propagation velocity
Psoriasis
C reactive protein
adult
aorta flow
Article
atherosclerosis
blood cell count
carotid artery
controlled study
female
human
leukocyte
lymphocyte
major clinical study
male
monocyte
neutrophil
neutrophil lymphocyte ratio
platelet lymphocyte ratio
psoriasis
Psoriasis Area and Severity Index
thrombocyte
aorta
arterial pressure
arterial wall thickness
blood
complication
echography
heart ventricle
middle aged
procedures
prospective study
randomized controlled trial
reproducibility
risk assessment
severity of illness index
statistics and numerical data
young adult
Adult
Aorta
Arterial Pressure
C-Reactive Protein
Carotid Intima-Media Thickness
Female
Heart Ventricles
Humans
Lymphocytes
Male
Middle Aged
Neutrophils
Prospective Studies
Reproducibility of Results
Risk Assessment
Severity of Illness Index
Young Adult
Publisher: Blackwell Publishing Inc.
Abstract: Background: Systemic inflammation beyond the skin may provide an explanation of the increased cardiovascular risk observed in psoriasis. It was hypothesized that neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are potential predictors of subclinical atherosclerosis measured by aortic velocity propagation (AVP) and carotid intima-media thickness (CIMT) in psoriasis. Methods: Fifty-one patients with psoriasis taking no antipsoriatic therapy and 37 age- and sex-matched healthy controls were prospectively enrolled. The Psoriasis Area and Severity Index (PASI) was calculated. Complete blood counts were obtained. Measurements of AVP and CIMT were performed. Results: The baseline clinical and demographic features, and white blood cell, platelet, neutrophil, lymphocyte, monocyte, and PLR were similar in both groups. NLR and high-sensitivity C-reactive protein (hs-CRP) were higher in the psoriasis group than the control group (P = 0.001, P < 0.001; respectively). The psoriasis group had lower AVP and higher CIMT values than those of controls (AVP: 48.9 ± 18.1 vs. 64.3 ± 14.5 cm/sec; P < 0.001, CIMT: 0.84 ± 0.29 vs. 0.63 ± 0.27 mm; P = 0.001, respectively). PASI was positively correlated with NLR and hs-CRP (r = 0.423, P = 0.002; r = 0.315, P = 0.024, respectively). There was an inverse association between AVP and CIMT (r = -0.749, P < 0.001). Binary logistic regression analysis demonstrated that NLR was the only variable able to predict lower AVP (?41 cm/sec) and higher CIMT (>0.9 mm) values (P = 0.024 and 0.023; respectively). Conclusion: NLR is potentially an unrecognized predictor of subclinical atherosclerosis in patients with psoriasis. Future studies assessing the prognostic significance of NLR on cardiovascular event rates in psoriasis patients would be of great interest. (Echocardiography 2014;31:1095-1104). © 2014, Wiley Periodicals, Inc.
URI: https://hdl.handle.net/11499/7797
https://doi.org/10.1111/echo.12511
ISSN: 0742-2822
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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