Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7816
Title: Increased Plasma High-sensitivity C-reactive protein and Myeloperoxidase Levels May Predict Ischemia During Myocardial Perfusion Imaging in Slow Coronary Flow
Authors: Yurtdaş, M.
Yaylalı, Yalın Tolga
Kaya, Y.
Özdemir, M.
Keywords: Coronary angiography
Coronary artery disease
Inflammatory cardiovascular risk factors
Myocardial perfusion imaging
C reactive protein
interleukin 6
myeloperoxidase
adult
angiocardiography
article
blood clot lysis
controlled study
coronary artery blood flow
female
heart muscle ischemia
heart muscle perfusion
human
human tissue
major clinical study
male
middle aged
myocardial perfusion imaging
protein blood level
single photon emission computer tomography
slow coronary flow
Adult
Biological Markers
C-Reactive Protein
Case-Control Studies
Coronary Angiography
Coronary Circulation
Female
Humans
Inflammation
Interleukin-6
Male
Middle Aged
Myocardial Ischemia
Myocardial Perfusion Imaging
Peroxidase
Abstract: Background and Aims: It is unclear whether changes in plasma levels of inflammatory markers could explain the link between ischemia and slow coronary flow (SCF). The aim of the study was to evaluate the plasma levels of high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, and myeloperoxidase (MPO) during myocardial perfusion imaging (MPI) in SCF patients. Methods: The study population consisted of 53 SCF patients and 30 controls. Coronary flow rates were documented by TIMI frame count (TFC). Plasma levels of hsCRP, IL-6, MPO, and MPI were obtained in all participants. Results: hsCRP, IL-6 and MPO levels of SCF patients were higher than controls (hsCRP: 4.7 ± 2.5 vs. 1.7 ± 1.1 mg/L, p <0.001; IL-6: 8.2 ± 4.3 vs. 5.2 ± 2.1 pg/mL, p <0.001; and MPO: 75.9 ± 59.6 vs. 24.3 ± 16.7 ng/mL, p <0.001). Twenty-one SCF patients exhibited myocardial perfusion defect (MPD) on MPI. In SCF patients, the highest hsCRP, IL-6 and MPO levels were observed in patients with both MPD and three-vessel slow flow. Mean TFCs were positively correlated with plasma levels of hsCRP (r= 0.424, p= 0.002), IL-6 (r= 0.367, p= 0.007), MPO (r= 0.430, p= 0.001), and reversibility score (r= 0.671, p <0.001) in SCF patients. HsCRP and MPO were the independent variables, which predicted positive MPI results (hsCRP: OR, 2.176; 95% CI, 1.200-3.943; p= 0.010, MPO: OR, 1.026; 95% CI, 1.007-1.046; p= 0.008). Conclusions: Inflammation may play a crucial role in both the pathogenesis and development of ischemia in SCF. Association of increased levels of inflammatory markers and ischemia suggests that endothelial inflammation may be largely responsible for clinical presentation. New combined treatment regimens should target endothelial activation and inflammation in SCF. © 2014 IMSS.
URI: https://hdl.handle.net/11499/7816
https://doi.org/10.1016/j.arcmed.2013.10.019
ISSN: 0188-4409
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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