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https://hdl.handle.net/11499/7841
Title: | Evaluation of the effect of selective serotonin reuptake inhibitors on bone mineral density: an observational cross-sectional study | Authors: | Ak, E. Bulut, S.D. Bulut, S. Akdağ, H.A. Öter, G.B. Kaya, H. Kaya, O.B. |
Keywords: | BMD GAD Osteoporosis SSRI citalopram paroxetine sertraline serotonin uptake inhibitor adult aged Article body mass bone density controlled study cross-sectional study disease duration drug effect female femur neck generalized anxiety disorder Hamilton Anxiety Scale Hamilton Depression Rating Scale human lesser trochanter lumbar spine lumbar vertebra major clinical study observational study osteoporosis postmenopause risk factor social aspect treatment duration Anxiety Disorders chemically induced drug effects femur middle aged pathophysiology postmenopause osteoporosis psychological rating scale Aged Bone Density Cross-Sectional Studies Female Femur Humans Lumbar Vertebrae Middle Aged Osteoporosis, Postmenopausal Psychiatric Status Rating Scales Serotonin Uptake Inhibitors |
Publisher: | Springer London | Abstract: | Summary: Sixty patients diagnosed with generalized anxiety disorder and treated with either paroxetine, sertraline, or citalopram for at least 12 months were enrolled in this study, and the bone mineral density (BMD) of the patients was compared with that of 40 healthy volunteers. Selective serotonin reuptake inhibitor (SSRI) therapy in generalized anxiety disorder was found to be related with decreased BMD values. Introduction: The objectives of this study were to evaluate the effect of SSRI therapy on BMD in postmenopausal women diagnosed with generalized anxiety disorder (GAD) and to identify the effects of the duration of disease and treatment on risk factors for osteoporosis. Methods: Sixty patients diagnosed with GAD and treated with paroxetine, sertraline, or citalopram from the SSRI group for at least 12 months were enrolled. Social demographic features, the Hamilton Anxiety Scale (HAS) results, and the Hamilton Depression Scale (HDS) scores of all the patients were assessed. The BMD of the patients was measured by dual-energy X-ray absorptiometry (DXA) at the femoral and lumbar regions. The patients were divided into three groups which are the paroxetine, sertraline, and citalopram groups. The BMD of the patients was compared with that of 40 healthy volunteers. Results: The L2–L4, total lumbar vertebrae, femoral intertrochanteric, total femoral Z-scores, and femoral Ward’s region T-scores of the treatment group were lower than the median T- and Z-scores of the control group (p < 0.05). Of the treatment groups, the femoral neck, trochanteric and intertrochanteric T- and Z-scores, total femoral T- and Z-scores, and femoral Ward’s T- and Z-scores of the sertraline group were significantly lower than the BMD values measured at the identical regions in the paroxetine and citalopram groups (p < 0.05).There was a significant negative correlation between the duration of treatment and the BMD values. Conclusion: SSRI therapy in GAD was found to be related with decreased BMD values. Further randomized controlled studies are warranted to determine whether SSRI use is a risk factor for osteoporosis; such studies should investigate these factors by performing BMD assessments before treatment. © 2014, The Author(s). |
URI: | https://hdl.handle.net/11499/7841 https://doi.org/10.1007/s00198-014-2859-2 |
ISSN: | 0937-941X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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