Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7859
Title: A multicenter nationwide reference intervals study for common biochemical analytes in Turkey using Abbott analyzers
Authors: Ozarda, Y.
Ichihara, K.
Aslan, Diler
Aybek, H.
Ari, Z.
Taneli, F.
Coker, C.
Keywords: biochemical parameters
common reference intervals
multicenter study
regional differences
Turkey
alanine aminotransferase
albumin
alkaline phosphatase
amylase
aspartate aminotransferase
bilirubin
bilirubin glucuronide
calcium
chloride
creatine kinase
creatinine
gamma glutamyltransferase
glucose
high density lipoprotein
lactate dehydrogenase
low density lipoprotein
magnesium
nitrogen
phosphate
potassium
protein
sodium
triacylglycerol
uric acid
inorganic compound
lipid
organic compound
plasma protein
adult
age
aged
alanine aminotransferase blood level
albumin blood level
alkaline phosphatase blood level
amylase blood level
analysis of variance
Article
aspartate aminotransferase blood level
bilirubin blood level
blood analysis
blood sampling
body mass
calcium blood level
chemical analyzer
chloride blood level
cholesterol blood level
controlled study
correlation analysis
creatine kinase blood level
creatinine blood level
female
gamma glutamyl transferase blood level
glucose blood level
human
lactate dehydrogenase blood level
lipoprotein blood level
magnesium blood level
male
multiple regression
nonparametric test
normal human
parametric test
phosphate blood level
potassium blood level
protein blood level
reference value
sex difference
sodium blood level
standardization
triacylglycerol blood level
Turk (people)
urea nitrogen blood level
uric acid blood level
blood
clinical chemistry
clinical trial
middle aged
multivariate analysis
standards
Adult
Age Factors
Aged
Analysis of Variance
Blood Proteins
Body Mass Index
Clinical Chemistry Tests
Female
Humans
Inorganic Chemicals
Lipids
Male
Middle Aged
Multivariate Analysis
Organic Chemicals
Reference Values
Publisher: Walter de Gruyter GmbH
Abstract: Background: A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and to explore sources of variation in reference values, including regionality. Methods: Blood samples were collected nationwide in 28 laboratories from the seven regions (?400 samples/region, 3066 in all). The sera were collectively analyzed in Uludag University in Bursa using Abbott reagents and analyzer. Reference materials were used for standardization of test results. After secondary exclusion using the latent abnormal values exclusion method, RIs were derived by a parametric method employing the modified Box-Cox formula and compared with the RIs by the non-parametric method. Three-level nested ANOVA was used to evaluate variations among sexes, ages and regions. Associations between test results and age, body mass index (BMI) and region were determined by multiple regression analysis (MRA). Results: By ANOVA, differences of reference values among seven regions were significant in none of the 25 analytes. Significant sex-related and age-related differences were observed for 10 and seven analytes, respectively. MRA revealed BMI-related changes in results for uric acid, glucose, triglycerides, high-density lipoprotein (HDL)-cholesterol, alanine aminotransferase, and ?-glutamyltransferase. Their RIs were thus derived by applying stricter criteria excluding individuals with BMI >28 kg/m2. Ranges of RIs by non-parametric method were wider than those by parametric method especially for those analytes affected by BMI. Conclusions: With the lack of regional differences and the well-standardized status of test results, the RIs derived from this nationwide study can be used for the entire Turkish population. © by De Gruyter 2014.
URI: https://hdl.handle.net/11499/7859
https://doi.org/10.1515/cclm-2014-0228
ISSN: 1434-6621
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

39
checked on Dec 14, 2024

WEB OF SCIENCETM
Citations

40
checked on Dec 19, 2024

Page view(s)

116
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.