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https://hdl.handle.net/11499/7864
Title: | Tear film and ocular surface changes in patients receiving systemic isotretinoin | Authors: | Çetin, Ebru Nevin Şanlı, Berna Bir, Ferda Yaldızkaya, Filiz Kaçar, Nida Yaylalı, Volkan |
Keywords: | Acne vulgaris Dry eye Impression cytology Isotretinoin Schirmer test Tear film break-up time isotretinoin acne vulgaris article clinical article dry eye goblet cell human impression cytology ocular surface disease prospective study scoring system tear film |
Abstract: | Purpose: Our aim in this study was to assess the ocular surface and tear film changes in acne vulgaris patients receiving systemic isotretinoin. Material and Method: Twenty-two eyes of 22 patients who received oral isotretinoin (roaccutane®, 0.7 mg/kg/day) for nodular acne vulgaris were enrolled in this prospective study. Tear film break-up time (BUT), Schirmer 1 test scores with anesthesia, ocular surface disease index (OSDI) scores and conjunctival impression cytology scores were recorded before treatment and at 3- and 6-month visits following the beginning of treatment. Results: BUT values decreased and OSDI scores significantly increased at 3 months after treatment (p=0.007 and p=0.018, paired samples test). Schirmer scores did not significantly change by isotretinoin treatment. Of 9 eyes with impression cytology specimens, 4 revealed normal conjunctival findings before treatment. At the 3rd month, there was an increase in the scores characterized by decrease of Goblet cells, and at 6 months of treatment, normal conjunctival findings did not exist in any of the patients (p=0.004, Friedman test). Discussion: Systemic isotretinoin treatment can cause alterations in the tear film and cause dry eye symptoms. | URI: | https://hdl.handle.net/11499/7864 https://doi.org/10.4274/tjo.87520 |
ISSN: | 1300-0659 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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10.4274 tjo.87520.pdf | 293.5 kB | Adobe PDF | View/Open |
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