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https://hdl.handle.net/11499/7967
Title: | Injection of specific amyloid-beta oligomers (beta1-40:Beta1-42510:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis | Authors: | Özdemir, Mehmet Bülent Erdoğan, Çağdaş Iwasaki, K. Watanabe, T. Ishikane, S. Fujiwara, M. |
Keywords: | A-beta Apoptosis Medial septal area Memory retention Water maze amyloid beta protein [1-40] amyloid beta protein [1-42] unclassified drug animal behavior animal experiment animal tissue apoptosis article controlled study forced swimming test hippocampal CA1 region hippocampal CA3 region hippocampus male memory disorder nerve function nick end labeling nonhuman rat septum nucleus spatial memory stereotactic procedure Amyloid beta-Peptides Animals CA1 Region, Hippocampal CA3 Region, Hippocampal Male Maze Learning Microinjections Peptide Fragments Rats Retention (Psychology) Septum of Brain |
Abstract: | Objectives: Because of the well-known neurochemical interactions between the septum and hippocampus during memory processes, we investigated the effect of amyloid-beta (A-beta) injection into the medial septum (MS) on the behavior in Wistar rats. We also assessed whether the observed effects were functional or due to apoptosis. Methods: Specific A-beta oligomers (beta1-40:beta1-42 510:1) were injected into MS for seven consecutive days. Behavior was assessed with the Morris water maze task. Results: Compared with the control group, rats that received A-beta oligomers exhibited significant memory retention impairment (P < 0.05) without apoptosis in the cornu ammonis (CA)1 and CA3 regions of the dorsal hippocampus. Discussion: These data indicate that septal injection of A-beta impairs memory retention, even in the absence of hippocampal apoptosis. This result might bring new insight to spatial memory-related disorders like Alzheimer's disease (AD). © W. S. Maney & Son Ltd 2013. | URI: | https://hdl.handle.net/11499/7967 https://doi.org/10.1179/1743132813Y.0000000195 |
ISSN: | 0161-6412 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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