Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7967
Title: Injection of specific amyloid-beta oligomers (beta1-40:Beta1-42510:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis
Authors: Özdemir, Mehmet Bülent
Erdoğan, Çağdaş
Iwasaki, K.
Watanabe, T.
Ishikane, S.
Fujiwara, M.
Keywords: A-beta
Apoptosis
Medial septal area
Memory retention
Water maze
amyloid beta protein [1-40]
amyloid beta protein [1-42]
unclassified drug
animal behavior
animal experiment
animal tissue
apoptosis
article
controlled study
forced swimming test
hippocampal CA1 region
hippocampal CA3 region
hippocampus
male
memory disorder
nerve function
nick end labeling
nonhuman
rat
septum nucleus
spatial memory
stereotactic procedure
Amyloid beta-Peptides
Animals
CA1 Region, Hippocampal
CA3 Region, Hippocampal
Male
Maze Learning
Microinjections
Peptide Fragments
Rats
Retention (Psychology)
Septum of Brain
Abstract: Objectives: Because of the well-known neurochemical interactions between the septum and hippocampus during memory processes, we investigated the effect of amyloid-beta (A-beta) injection into the medial septum (MS) on the behavior in Wistar rats. We also assessed whether the observed effects were functional or due to apoptosis. Methods: Specific A-beta oligomers (beta1-40:beta1-42 510:1) were injected into MS for seven consecutive days. Behavior was assessed with the Morris water maze task. Results: Compared with the control group, rats that received A-beta oligomers exhibited significant memory retention impairment (P < 0.05) without apoptosis in the cornu ammonis (CA)1 and CA3 regions of the dorsal hippocampus. Discussion: These data indicate that septal injection of A-beta impairs memory retention, even in the absence of hippocampal apoptosis. This result might bring new insight to spatial memory-related disorders like Alzheimer's disease (AD). © W. S. Maney & Son Ltd 2013.
URI: https://hdl.handle.net/11499/7967
https://doi.org/10.1179/1743132813Y.0000000195
ISSN: 0161-6412
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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