Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7980
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dc.contributor.authorYay, A.-
dc.contributor.authorAbban, Gülçin-
dc.contributor.authorKutlubay, Recep-
dc.date.accessioned2019-08-16T12:34:01Z-
dc.date.available2019-08-16T12:34:01Z-
dc.date.issued2013-
dc.identifier.issn1300-199X-
dc.identifier.urihttps://hdl.handle.net/11499/7980-
dc.identifier.urihttps://doi.org/10.5152/etd.2013.17-
dc.description.abstractObjective: Cadherins are a protein family of Ca2+ dependent transmembrane cell adhesion molecules that play a key role in the regulation of organ and tissue development during embriyogenesis. We aimed to show E-cadherin expression immunohistochemically in the pre-natal period in the development of kidney. Materials and Methods: In this study, 45 fetuses were obtained from 12 female and 4 male adult Wistar rats bred in Pamukkale University Experimental Research Unit. Fetuses were removed from 11, 13, 15, 17 and 19. day pregnant rats. After routine light microscopy technique, fetuses fixed in 10% formaldehyde were embedded in paraffin. Serial 5 µ thick sections from parafin blocks were taken to slides and the immunohistochemistry method, was applied to determine the E-cadherin expression. Results: In this study, E-cadherin showed negative expression in E11 and 13 days kidney tissues. In the 15, 17 and 19. day kidneys, E-cadherin expression was positive. Tubule structures were more darkly stained than glomerular structures. In lateterm fetal kidneys, E-cadherin expression was gradually diminished in the renal corpuscle. Conclusion: We determined that E-cadherin expression showed differences both in different developmental stages and different areas of kidney. These differences may be important in terms of the investigation of etiologies and diagnosis of congenital kidney diseases and in the evaluation of nephrotoxicity and kidney pathologies. © 2013 by Erciyes University School of Medicine.en_US
dc.language.isoenen_US
dc.relation.ispartofErciyes Tip Dergisien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectE-cadherinen_US
dc.subjectFetal developmenten_US
dc.subjectKidneyen_US
dc.subjectRaten_US
dc.subjectuvomorulinen_US
dc.subjectanimal tissueen_US
dc.subjectarticleen_US
dc.subjectfemaleen_US
dc.subjectfetusen_US
dc.subjectimmunohistochemistryen_US
dc.subjectkidney developmenten_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectprenatal developmenten_US
dc.subjectprotein expressionen_US
dc.subjectraten_US
dc.titleImmunohistochemical demonstration of E-Cadherin expression in the kidney of prenatal developmenten_US
dc.title.alternativeDoğum öncesi dönemde böbrek gelişiminde E-Cadherin ekspresyonunun immunohistokimyasal olarak gösterilmesien_US
dc.typeArticleen_US
dc.identifier.volume35en_US
dc.identifier.issue3en_US
dc.identifier.startpage114en_US
dc.identifier.endpage119en_US
dc.identifier.doi10.5152/etd.2013.17-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-84884361570en_US
dc.identifier.trdizinid152481en_US
dc.identifier.wosWOS:000421239400004en_US
dc.identifier.scopusqualityQ4-
dc.ownerPamukkale University-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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