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https://hdl.handle.net/11499/8040
Title: | The protective effect of docosahexaenoic acid on the bilirubin neurotoxicity | Authors: | Becerir, Cem Kılıç, İlknur Şahin, Özlem Özdemir, Özmert Tokgün, Onur Özdemir, Bülent Akca, Hakan |
Keywords: | Astrocyte Docosahexaenoic acid Neurotoxicity Unconjugated bilirubin bilirubin catalase docosahexaenoic acid glutathione peroxidase superoxide dismutase animal cell apoptosis article astrocyte bilirubin blood level cell culture cell viability concentration (parameters) concentration response controlled study cytotoxicity enzyme activity enzyme inhibition neuroprotection neurotoxicity newborn jaundice nonhuman priority journal rat Animals Antioxidants Apoptosis Astrocytes Bilirubin Catalase Cell Survival Cells, Cultured Docosahexaenoic Acids Dose-Response Relationship, Drug Glutathione Peroxidase Rats Rats, Wistar Structure-Activity Relationship Superoxide Dismutase |
Abstract: | Usually, all newborns demonstrate high serum unconjugated bilirubin (UCB) level. UCB may induce adverse effects in the central nervous system. We aimed to evaluate the cytotoxic effects of UCB and the protective effects of docosahexaenoic acid (DHA) on astrocyte cell cultures. The viability of astrocyte cells decreased after UCB treatment in a dose-dependent manner. Pre-incubation of DHA prevents the cells from UCB-mediated neurotoxicity. Our results shown that UCB leads to inhibition of antioxidant enzymes superoxide dismutase (SOD), catalase and GPx activity and induction of apoptosis. But only 4-h pretreatment of DHA can suppress of UCB-mediated inhibition of antioxidant enzymes SOD, catalase and GPx activity and induction of apoptosis in astrocytes. Our results strongly indicated that DHA has a protective effect on UCB-mediated neurotoxicity through inhibition apoptosis and antioxidant enzymes activity of SOD, CAT and GPx in rat primer astrocyte cell line © 2013 Informa UK, Ltd. | URI: | https://hdl.handle.net/11499/8040 https://doi.org/10.3109/14756366.2012.684053 |
ISSN: | 1475-6366 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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10.3109 14756366.2012.684053.pdf | 920.48 kB | Adobe PDF | View/Open |
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