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https://hdl.handle.net/11499/8051
Title: | Association of synapsin III gene with adult attention deficit hyperactivity disorder | Authors: | Kenar, Ayşe Nur İnci Edgünlü, Tuba Herken, Hasan Erdal, Mehmet Emin |
Keywords: | genomic DNA phosphoprotein synapsin III unclassified drug adult adult disease allele article attention deficit disorder comparative study controlled study DNA polymorphism female gene frequency genetic analysis genetic association genotype human major clinical study male priority journal Adult Age of Onset Alleles Attention Deficit Disorder with Hyperactivity Case-Control Studies Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Male Polymorphism, Single Nucleotide Synapsins Young Adult |
Abstract: | It was aimed to investigate the association of the synapsin III gene -196 G> A and -631 C>G polymorphisms that takes place in an encoding presynaptic protein, with adult attention deficit hyperactivity disorder (ADHD). One hundred thirty-nine patients having adult ADHD and 106 controls were included in the study. DNA samples were extracted from whole blood and genetic analyses were performed. A significant difference was determined between ADHD and synapsin III gene -631 C>G polymorphism compared to the control group. No significant difference was determined between ADHD and synapsin III gene -196 G>A polymorphism. These polymorphisms were found not to be associated with subtypes of ADHD. It is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of ADHD. © Copyright 2013, Mary Ann Liebert, Inc. 2013. | URI: | https://hdl.handle.net/11499/8051 https://doi.org/10.1089/dna.2012.1937 |
ISSN: | 1044-5498 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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