Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8102
Title: Serum calcitonin gene-related peptide levels in women with polycystic ovary syndrome
Authors: Fenkci, S.M.
Fenkçi, Veysel
Öztekin, Özer
Rota, Simin
Keywords: CGRP
Dyslipidemia
Insulin resistance
PCOS
androgen
calcitonin gene related peptide
glucose
gonadotropin
high density lipoprotein cholesterol
insulin
low density lipoprotein cholesterol
acne
adolescent
adult
article
cholesterol blood level
clinical article
controlled clinical trial
controlled study
dyslipidemia
female
glucose blood level
hirsutism
homeostasis
human
hyperandrogenism
insulin blood level
insulin resistance
oligomenorrhea
ovary polycystic disease
pathogenesis
postprandial state
protein blood level
transvaginal echography
Adolescent
Adult
Androgens
Blood Glucose
Calcitonin Gene-Related Peptide
Cholesterol, HDL
Fasting
Female
Humans
Hyperandrogenism
Hyperlipidemias
Insulin
Insulin Resistance
Lipids
Obesity, Abdominal
Polycystic Ovary Syndrome
Postprandial Period
Waist Circumference
Abstract: Purpose: Calcitonin gene-related peptide (CGRP) is an amino acid neuropeptide with widespread expression. It has potent effects on lipid and energy metabolism. It induces insulin resistance. This study was planned to determine CGRP levels in women with polycystic ovary syndrome (PCOS). Methods: Forty-seven women with PCOS and 34 healthy controls were evaluated in this controlled clinical study. Serum lipid sub-fractions, postprandial and fasting glucose, insulin and other hormones (gonadotropins, androgens) and CGRP levels were measured. Homeostasis model assessment (HOMA-IR) was used to estimate insulin resistance. Results: Waist measurements, postprandial and fasting glucose and fasting insulin levels and free androgen index and HOMA-IR were significantly higher in subjects with PCOS. However, the women with PCOS had considerably lower high-density lipoprotein cholesterol levels than healthy subjects. Serum CGRP levels were higher in study subjects than in controls, although it was statistically insignificant. Conclusions: Serum CGRP level was not related with insulin resistance, ovarian hyperandrogenism and dyslipidemia in abdominally obese women with PCOS. These outcomes propose that CGRP may not play a pivotal role in the pathogenesis of PCOS. © 2012 Springer-Verlag Berlin Heidelberg.
URI: https://hdl.handle.net/11499/8102
https://doi.org/10.1007/s00404-012-2689-4
ISSN: 0932-0067
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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