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https://hdl.handle.net/11499/8107
Title: | Therapeutic plasma exchange in patients with neurological diseases: Multicenter retrospective analysis | Authors: | Kaya, E. Keklik, M. Şencan, M. Yilmaz, M. Keskin, Ali Kiki, T. Erkurt, M.A. |
Keywords: | Acute disseminated encephalomyelitis Chronic inflammatory demyelinating polyradiculoneuropathy Guillain-Barre syndrome Multiple sclerosis Myasthenia gravis Therapeutic plasma exchange fresh frozen plasma human albumin acute disseminated encephalomyelitis adolescent adult aged allergic reaction article catheter complication central venous catheter child female Guillain Barre syndrome human hypocalcemia hypotension major clinical study male medical record review multicenter study multiple sclerosis myasthenia gravis neurologic disease peripheral venous catheter plasmapheresis polyradiculoneuropathy preschool child retrospective study school child tachycardia university hospital Wilson disease Adolescent Adult Aged Aged, 80 and over Albumins Blood Component Removal Child Child, Preschool Encephalomyelitis, Acute Disseminated Female Guillain-Barre Syndrome Humans Male Middle Aged Multiple Sclerosis Myasthenia Gravis Plasma Exchange Polyradiculoneuropathy, Chronic Inflammatory Demyelinating Retrospective Studies Treatment Outcome Young Adult |
Abstract: | Therapeutic plasma exchange (TPE), is a procedure, changing pathologic substances in the plasma of patients with replacement fluid. TPE has an increasing list of indications in recent years such as neurological, connective tissue, hematological, nephrological, endocrinological and metabolic disorders. We report our multicenter data about therapeutic plasma exchange in patients with neurological diseases. Six University Hospitals' aphaeresis units medical records about neurologic diseases were reviewed retrospectively. Hundred and fifteen patients and 771 TPE sessions from six aphaeresis units' were included to this study. Of the 115 patients, 53 (46%) were men and 62 (54%) were women. The median age was 50 (range: 5-85) years. Of these patients 58.3% were Guillain-Barre syndrome (GBS), 17.4% were acute disseminated encephalomyelitis (ADEM), 10.4% were chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 7% were multiple sclerosis, 6.1% were myasthenia gravis (MG) and 0.9% were Wilson disease (WD). The median number of TPE sessions per patient was 5 (range 1-72). Human albumin was used as a replacement fluid in 66% and fresh frozen plasma was used in 34% of cases. TPE was done through central venous catheters in 66%, and peripheral venous access in 34% of patients. Some complications were seen in patients (18.3%) during TPE sessions. These complications were, complications related to catheter placement procedure (8.7%), hypotension (3.5%), hypocalcaemia (3.5%) and allergic reactions (1.7%). The complication ratios were 2.7% in total 771 TPE procedures. TPE procedure was terminated in 6% of sessions depending on these complications. Overall responses to TPE were noted in 89.5% of patients.In conclusion; Therapeutic plasma exchange is an effective treatment option in several neurologic diseases. © 2013 Elsevier Ltd. | URI: | https://hdl.handle.net/11499/8107 https://doi.org/10.1016/j.transci.2013.04.015 |
ISSN: | 1473-0502 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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