Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8109
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dc.contributor.authorMenzies, S.W.-
dc.contributor.authorMoloney, F.J.-
dc.contributor.authorByth, K.-
dc.contributor.authorAvramidis, M.-
dc.contributor.authorArgenziano, G.-
dc.contributor.authorZalaudek, I.-
dc.contributor.authorBraun, R.P.-
dc.date.accessioned2019-08-16T12:35:35Z-
dc.date.available2019-08-16T12:35:35Z-
dc.date.issued2013-
dc.identifier.issn2168-6068-
dc.identifier.urihttps://hdl.handle.net/11499/8109-
dc.identifier.urihttps://doi.org/10.1001/jamadermatol.2013.2466-
dc.description.abstractImportance: Nodular melanoma (NM) is a rapidly progressing potentially lethal skin tumor for which early diagnosis is critical. Objective: To determine the dermoscopy features of NM. Design: Eighty-three cases of NM, 134 of invasive non- NM, 115 of nodular benign melanocytic tumors, and 135 of nodular nonmelanocytic tumors were scored for dermoscopy features using modified and previously described methods. Lesions were separated into amelanotic/ hypomelanotic or pigmented to assess outcomes. Setting: Predominantly hospital-based clinics from 5 continents. Main Outcome Measures: Sensitivity, specificity, and odds ratios for features/models for the diagnosis of melanoma. Results: Nodular melanoma occurred more frequently as amelanotic/hypomelanotic (37.3%) than did invasive non-NM (7.5%). Pigmented NM had a more frequent (compared with invasive non-NM; in descending order of odds ratio) symmetrical pigmentation pattern (5.8% vs 0.8%), large-diameter vessels, areas of homogeneous blue pigmentation, symmetrical shape, predominant peripheral vessels, blue-white veil, pink color, black color, and milky red/pink areas. Pigmented NM less frequently displayed an atypical broadened network, pigment network or pseudonetwork, multiple blue-gray dots, scarlike depigmentation, irregularly distributed and sized brown dots and globules, tan color, irregularly shaped depigmentation, and irregularly distributed and sized dots and globules of any color. The most important positive correlating features of pigmented NM vs nodular nonmelanoma were peripheral black dots/globules, multiple brown dots, irregular black dots/globules, bluewhite veil, homogeneous blue pigmentation, 5 to 6 colors, and black color. A model to classify a lesion as melanocytic gave a high sensitivity (98.0%) for both nodular pigmented and nonnodular pigmented melanoma but a lower sensitivity for amelanotic/ hypomelanoticNM(84%). A method for diagnosing amelanotic/hypomelanotic malignant lesions (including basal cell carcinoma) gave a 93% sensitivity and 70% specificity for NM. Conclusions and Relevance: When a progressively growing, symmetrically patterned melanocytic nodule is identified, NM needs to be excluded. © 2013 American Medical Association.en_US
dc.language.isoenen_US
dc.relation.ispartofJAMA Dermatologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectarticleen_US
dc.subjectbasal cell carcinomaen_US
dc.subjectdiagnostic procedureen_US
dc.subjectdiagnostic test accuracy studyen_US
dc.subjectepiluminescence microscopyen_US
dc.subjecthospitalen_US
dc.subjecthumanen_US
dc.subjectinvasive non nodular melanomaen_US
dc.subjectmajor clinical studyen_US
dc.subjectmedical assessmenten_US
dc.subjectmelanomaen_US
dc.subjectnodular benign melanocytic tumoren_US
dc.subjectnodular nonmelanocytic tumoren_US
dc.subjectoutcome assessmenten_US
dc.subjectpriority journalen_US
dc.subjectrisken_US
dc.subjectscoring systemen_US
dc.subjectsensitivity and specificityen_US
dc.subjectskin pigmentationen_US
dc.subjectskin tumoren_US
dc.subjectDermoscopyen_US
dc.subjectDisease Progressionen_US
dc.subjectHumansen_US
dc.subjectMelanomaen_US
dc.subjectPigmentationen_US
dc.subjectSensitivity and Specificityen_US
dc.subjectSkin Neoplasmsen_US
dc.titleDermoscopic evaluation of nodular melanomaen_US
dc.typeArticleen_US
dc.identifier.volume149en_US
dc.identifier.issue6en_US
dc.identifier.startpage699
dc.identifier.startpage699en_US
dc.identifier.endpage709en_US
dc.identifier.doi10.1001/jamadermatol.2013.2466-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid23553375en_US
dc.identifier.scopus2-s2.0-84879330371en_US
dc.identifier.wosWOS:000320857700008en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.grantfulltextopen-
item.cerifentitytypePublications-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
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Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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