Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8140
Title: Diabetes care, glycemic control, complications, and concomitant autoimmune diseases in children with type 1 diabetes in Turkey: A multicenter study
Authors: Şimsek, D.G.
Aycan, Z.
Özen, S.
Çetinkaya, S.
Kara, C.
Abali, S.
Demir, K.
Keywords: Children
Complications
Turkey
Type 1 diabetes
albumin
cholesterol
creatinine
hemoglobin A1c
high density lipoprotein cholesterol
insulin
low density lipoprotein cholesterol
protein glutamine gamma glutamyltransferase antibody
thyroglobulin antibody
thyroid peroxidase
thyrotropin
thyrotropin receptor antibody
thyroxine
adolescent
adult
article
autoimmune disease
blood pressure
celiac disease
child
continuous infusion
cross-sectional study
dyslipidemia
electromyography
female
follow up
glycemic control
Graves disease
Hashimoto disease
human
hyperglycemia
hypoglycemia
infant
insulin dependent diabetes mellitus
insulin pump
ketoacidosis
major clinical study
male
metabolic regulation
microalbuminuria
neuropathy
newborn
obesity
ophthalmoscopy
preschool child
retinopathy
school child
scoring system
short stature
Adolescent
Autoimmune Diseases
Blood Glucose
Child
Child, Preschool
Cross-Sectional Studies
Diabetes Mellitus, Type 1
Female
Hemoglobin A, Glycosylated
Humans
Infant
Insulin
Male
Obesity
Young Adult
Abstract: Objective: Epidemiologic and clinical features of type 1 diabetes mellitus (T1DM) may show substantial differences among countries. The primary goal in the management of T1DM is to prevent micro-and macrovascular complications by achieving good glycemic control. The present study aimed to assess metabolic control, presence of concomitant autoimmune diseases, and of acute and long-term complications in patients diagnosed with T1DM during childhood and adolescence. The study also aimed to be a first step in the development of a national registry system for T1DM, in Turkey. Methods: Based on hospital records, this cross-sectional, multicenter study included 1 032 patients with T1DM from 12 different centers in Turkey, in whom the diagnosis was established during childhood. Epidemiological and clinical characteristics of the patients were recorded. Metabolic control, diabetes care, complications, and concomitant autoimmune diseases were evaluated. Results: Mean age, diabetes duration, and hemoglobin A1c level were 12.5±4.1 years, 4.7±3.2 years, and 8.5±1.6%, respectively. Acute complications noted in the past year included ketoacidosis in 5.2% of the patients and severe hypoglycemia in 4.9%. Chronic lymphocytic thyroiditis was noted in 12%, Graves' disease in 0.1%, and celiac disease in 4.3% of the patients. Chronic complications including neuropathy, retinopathy, and persistent microalbuminuria were present in 2.6%, 1.4%, and 5.4% of the patients, respectively. Diabetic nephropathy was not present in any of the patients. Mean diabetes duration and age of patients with neuropathy, retinopathy and microalbuminuria were significantly different from the patients without these long-term complications (p<0.01). A significant difference was found between pubertal and prepubertal children in terms of persistent microalbuminuria and neuropathy (p=0.02 and p<0.001, respectively). Of the patients, 4.4% (n:38) were obese and 5% had short stature; 17.4% of the patients had dyslipidemia, and 14% of the dyslipidemic patients were obese. Conclusions: Although the majority of the patients in the present study were using insulin analogues, poor glycemic control was common, and chronic complications were encountered. © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing.
URI: https://hdl.handle.net/11499/8140
https://doi.org/10.4274/Jcrpe.893
ISSN: 1308-5727
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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