Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8211
Title: Gastric histopathological findings and Ghrelin expression in morbid obesity
Other Titles: Morbid obezitede gastrik histopatolojik bulgular ve Ghrelin ekspresyonu
Authors: Gündogan, Mehmet
Çallı Demirkan, Neşe
Tekin, Koray
Aybek, Hülya
Keywords: Ghrelin
Morbid obesity
Stomach
chromogranin A
ghrelin
adult
article
body mass
clinical article
controlled study
coronary artery disease
diabetes mellitus
female
Helicobacter pylori
histopathology
human
hyperplasia
hypertension
immunohistochemistry
lymphocytic infiltration
male
morbid obesity
prospective study
protein expression
stomach
Adolescent
Adult
Case-Control Studies
Cell Count
Chromogranins
Enteroendocrine Cells
Female
Gastrectomy
Gastric Mucosa
Humans
Male
Middle Aged
Obesity, Morbid
Young Adult
Abstract: Objective: The role of Ghrelin, also known as the appetite hormone, is not fully explained in the development of morbid obesity. Plasma Ghrelin level is low in obese and high in slim subjects. Ghrelin-expressing cells were investigated histopathologically in the stomach of morbid obese patients in this study. Tissue Ghrelin expression was also compared with various parameters such as the distribution of endocrine cells, age, gender, body mass index, preoperative plasma Ghrelin level and presence of accompanying diseases. Material and Method: The study included 33 morbidly obese patients, and 8 non-obese control patients. Plasma Ghrelin levels were measured preoperatively. Sleeve gastrectomy resection materials of 33 cases were evaluated with histopathological and immunohistochemical (Ghrelin and Chromogranin-A) techniques. The results were statistically evaluated by nonparametric tests. Results: Histopathological findings observed in sleeve gastrectomy resection materials were interstitial lymphocytic infiltration (63.6%), hyperplasia of lymphoid follicles in the lamina propria (60.7%) and microvesiculation / dilatation of parietal cells (57.6%). The number of Ghrelin immunopositive cells in the gastric mucosa in females was significantly higher compared to males (p=0,007). Additionally, the number of Ghrelin immunopositive cells was significantly higher at the fundus-proximal corpus compared to the distal corpus of the stomach (p=0.0001). No significant correlation was found between Ghrelin-chromogranin immunopositive endocrine cell distribution and preoperative plasma Ghrelin levels and endocrine cell hyperplasia. Conclusion: Our study confirms that Ghrelin producing cells are most dense in the proximal stomach. Increased number of Ghrelin expressing cells in the gastric mucosa in females compared to males suggests that gender may also be a factor in determining the method for treatment of morbid obesity.
URI: https://hdl.handle.net/11499/8211
https://doi.org/10.5146/tjpath.2013.01143
ISSN: 1018-5615
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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