Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8252
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dc.contributor.authorTaşlı, Levent-
dc.contributor.authorTurgut, Sebahat-
dc.contributor.authorKaçar, Nida-
dc.contributor.authorAyada, Ceylan-
dc.contributor.authorÇoban, Melis-
dc.contributor.authorAkçılar, Raziye-
dc.contributor.authorErgin, Şeniz-
dc.date.accessioned2019-08-16T12:37:39Z
dc.date.available2019-08-16T12:37:39Z
dc.date.issued2013-
dc.identifier.issn1468-3083-
dc.identifier.urihttps://hdl.handle.net/11499/8252-
dc.identifier.urihttps://doi.org/10.1111/j.1468-3083.2011.04299.x-
dc.description.abstractAcne vulgaris is a multifactorial disease of the skin. Several studies have shown that elevated levels of serum insulin-like growth factor-I (IGF-I) correlate with overproduction of sebum and acne. Recently functional relationship between IGF-I (CA) polymorphism and circulating IGF-I levels in adults has been reported. The aim of our study was to investigate for the first time whether IGF-I (CA) polymorphism might be involved in the pathogenesis of acne or not. We included 115 acne patients and 117 healthy subjects to the study. The clinical grade of acne was assessed based on the Global Acne Grading System. Participants were questioned about diabetes mellitus, PCOS and other systemic disease. We searched for the IGF-I (CA) 19 polymorphism in this study. The IGF-I (CA) 19 polymorphism was performed by polymerase chain reaction. We categorized the IGF-I (CA) 19 polymorphism area into three groups as lower than 192 bp, 192-194 bp and higher than 194 bp. We found that the frequency of genotype IGF-1 (CA) 19 gene was significantly different between control and acne patients (P = 0.0002). A significant association between IGF-I (CA) genotypes and severity of acne was found (P = 0.015). No significant difference was found between male and female patients (P > 0.05). Our results suggest that IGF-I (CA) 19 polymorphism may contribute to a predisposition to acne in Turkish patients.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of the European Academy of Dermatology and Venereology : JEADVen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectprimer DNAen_US
dc.subjectsomatomedin Cen_US
dc.subjectacne vulgarisen_US
dc.subjectarticleen_US
dc.subjectcase control studyen_US
dc.subjectfemaleen_US
dc.subjectgenetic polymorphismen_US
dc.subjectgeneticsen_US
dc.subjecthumanen_US
dc.subjectmaleen_US
dc.subjectnucleotide sequenceen_US
dc.subjectpolymerase chain reactionen_US
dc.subjectAcne Vulgarisen_US
dc.subjectBase Sequenceen_US
dc.subjectCase-Control Studiesen_US
dc.subjectDNA Primersen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectInsulin-Like Growth Factor Ien_US
dc.subjectMaleen_US
dc.subjectPolymerase Chain Reactionen_US
dc.subjectPolymorphism, Geneticen_US
dc.titleInsulin-like growth factor-I gene polymorphism in acne vulgaris.en_US
dc.typeArticleen_US
dc.identifier.volume27en_US
dc.identifier.issue2en_US
dc.identifier.startpage254
dc.identifier.startpage254en_US
dc.identifier.endpage257en_US
dc.authorid0000-0002-5433-4394-
dc.authorid0000-0001-8730-8056-
dc.authorid0000-0002-6272-4173-
dc.authorid0000-0003-4720-1945-
dc.authorid0000-0003-0426-6685-
dc.authorid0000-0002-7884-5623-
dc.identifier.doi10.1111/j.1468-3083.2011.04299.x-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid23457723en_US
dc.identifier.scopus2-s2.0-84877921778en_US
dc.identifier.wosWOS:000313883900047en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeArticle-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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