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https://hdl.handle.net/11499/8252
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Taşlı, Levent | - |
dc.contributor.author | Turgut, Sebahat | - |
dc.contributor.author | Kaçar, Nida | - |
dc.contributor.author | Ayada, Ceylan | - |
dc.contributor.author | Çoban, Melis | - |
dc.contributor.author | Akçılar, Raziye | - |
dc.contributor.author | Ergin, Şeniz | - |
dc.date.accessioned | 2019-08-16T12:37:39Z | |
dc.date.available | 2019-08-16T12:37:39Z | |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1468-3083 | - |
dc.identifier.uri | https://hdl.handle.net/11499/8252 | - |
dc.identifier.uri | https://doi.org/10.1111/j.1468-3083.2011.04299.x | - |
dc.description.abstract | Acne vulgaris is a multifactorial disease of the skin. Several studies have shown that elevated levels of serum insulin-like growth factor-I (IGF-I) correlate with overproduction of sebum and acne. Recently functional relationship between IGF-I (CA) polymorphism and circulating IGF-I levels in adults has been reported. The aim of our study was to investigate for the first time whether IGF-I (CA) polymorphism might be involved in the pathogenesis of acne or not. We included 115 acne patients and 117 healthy subjects to the study. The clinical grade of acne was assessed based on the Global Acne Grading System. Participants were questioned about diabetes mellitus, PCOS and other systemic disease. We searched for the IGF-I (CA) 19 polymorphism in this study. The IGF-I (CA) 19 polymorphism was performed by polymerase chain reaction. We categorized the IGF-I (CA) 19 polymorphism area into three groups as lower than 192 bp, 192-194 bp and higher than 194 bp. We found that the frequency of genotype IGF-1 (CA) 19 gene was significantly different between control and acne patients (P = 0.0002). A significant association between IGF-I (CA) genotypes and severity of acne was found (P = 0.015). No significant difference was found between male and female patients (P > 0.05). Our results suggest that IGF-I (CA) 19 polymorphism may contribute to a predisposition to acne in Turkish patients. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of the European Academy of Dermatology and Venereology : JEADV | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | primer DNA | en_US |
dc.subject | somatomedin C | en_US |
dc.subject | acne vulgaris | en_US |
dc.subject | article | en_US |
dc.subject | case control study | en_US |
dc.subject | female | en_US |
dc.subject | genetic polymorphism | en_US |
dc.subject | genetics | en_US |
dc.subject | human | en_US |
dc.subject | male | en_US |
dc.subject | nucleotide sequence | en_US |
dc.subject | polymerase chain reaction | en_US |
dc.subject | Acne Vulgaris | en_US |
dc.subject | Base Sequence | en_US |
dc.subject | Case-Control Studies | en_US |
dc.subject | DNA Primers | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Insulin-Like Growth Factor I | en_US |
dc.subject | Male | en_US |
dc.subject | Polymerase Chain Reaction | en_US |
dc.subject | Polymorphism, Genetic | en_US |
dc.title | Insulin-like growth factor-I gene polymorphism in acne vulgaris. | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 254 | |
dc.identifier.startpage | 254 | en_US |
dc.identifier.endpage | 257 | en_US |
dc.authorid | 0000-0002-5433-4394 | - |
dc.authorid | 0000-0001-8730-8056 | - |
dc.authorid | 0000-0002-6272-4173 | - |
dc.authorid | 0000-0003-4720-1945 | - |
dc.authorid | 0000-0003-0426-6685 | - |
dc.authorid | 0000-0002-7884-5623 | - |
dc.identifier.doi | 10.1111/j.1468-3083.2011.04299.x | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 23457723 | en_US |
dc.identifier.scopus | 2-s2.0-84877921778 | en_US |
dc.identifier.wos | WOS:000313883900047 | en_US |
dc.identifier.scopusquality | Q1 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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