Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8253
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dc.contributor.authorGürbulak, Sabriye-
dc.contributor.authorYaylalı, Güzin Fidan-
dc.contributor.authorYerlikaya, Emrah-
dc.contributor.authorAkın, Fulya-
dc.contributor.authorTopsakal, Şenay-
dc.contributor.authorTanrıverdi, Halil-
dc.contributor.authorAkdağ, Beyza-
dc.date.accessioned2019-08-16T12:37:40Z-
dc.date.available2019-08-16T12:37:40Z-
dc.date.issued2013-
dc.identifier.issn1708-8267-
dc.identifier.urihttps://hdl.handle.net/11499/8253-
dc.identifier.urihttps://doi.org/10.2310/JIM.0b013e3182823390-
dc.description.abstractPurpose: To find out how resistin and leptin levels were affected in patients with acromegaly and whether there is a relation between resistin levels and cardiac parameters. We also aimed to investigate whether resistin and leptin may be a link between insulin resistance and cardiac functions as well as these affected cardiac functions in the patients with acromegaly. Methods: We included 30 subjects (15 men and 15 women) who had a diagnosis of acromegaly and 30 healthy (10 men and 20 women) subjects. Serum glucose, insulin, growth hormone, insulinlike growth factor 1 (IGF-1), resistin, and leptin levels were obtained, and insulin resistance of subjects were calculated. Echocardiographic studies of the subjects were performed. Results: Resistin levels of the patientswith acromegaly were found lower than controls. This difference was statistically significant (P = 0.001). Leptin levels were lower in the patients with acromegaly than in the controls, but this difference was not statistically significant. Resistin and leptin levels were not correlated with growth hormone, IGF-1, and with insulinlike growth factor binding protein 3 levels. Homeostasis model assessment of insulin resistance was positively correlated with resistin levels. (P = 0.03; r = 0.531) but not correlated with leptin levels. There was a positive correlation between body mass index and leptin levels in the patients with acromegaly (P = 0.007; r = 0.482). Interventricular septum thickness, posterior wall thickness, left ventricle mass index, peak early mitral inflow velocity-peak late mitral inflow velocity ratio, deceleration time, ejection time, isovolumetric relaxation time, velocity propagation, and left ventricular end-systolic volume values were significantly greater in the patients with acromegaly. Leptin levels in the acromegalic patients were not correlated with any of them. Conclusions: We found biventricular hypertrophy and impairment of diastolic and systolic function in the patients with acromegaly. We conclude that changes in resistin and leptin levels are unlikely to account for the insulin resistance of acromegaly. They do not also seem to be contributing factors of cardiovascular changes in patients with acromegaly. Copyright © 2013 by The American Federation for Medical Research.en_US
dc.language.isoenen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.ispartofJournal of Investigative Medicineen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcromegalyen_US
dc.subjectLeptinen_US
dc.subjectResistinen_US
dc.subjectglucoseen_US
dc.subjectgrowth hormoneen_US
dc.subjectinsulinen_US
dc.subjectleptinen_US
dc.subjectresistinen_US
dc.subjectsomatomedin binding protein 3en_US
dc.subjectsomatomedin Cen_US
dc.subjectacromegalyen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectblood flow velocityen_US
dc.subjectbody massen_US
dc.subjectcardiovascular parametersen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectdisease associationen_US
dc.subjectechocardiographyen_US
dc.subjectfemaleen_US
dc.subjectglucose blood levelen_US
dc.subjectheart functionen_US
dc.subjectheart left ventricle ejection timeen_US
dc.subjectheart left ventricle endsystolic volumeen_US
dc.subjectheart left ventricle massen_US
dc.subjectheart ventricle hypertrophyen_US
dc.subjectheart ventricle wallen_US
dc.subjecthomeostasisen_US
dc.subjecthumanen_US
dc.subjectinsulin blood levelen_US
dc.subjectinsulin resistanceen_US
dc.subjectinterventricular septum thicknessen_US
dc.subjectleft ventricular diastolic dysfunctionen_US
dc.subjectleft ventricular systolic dysfunctionen_US
dc.subjectmaleen_US
dc.subjectpeak early mitral inflow velocity peak late mitral inflow velocity ratioen_US
dc.subjectprotein blood levelen_US
dc.titleResistin and leptin levels in acromegaly: Lack of correlation With echocardiographic findingsen_US
dc.typeArticleen_US
dc.identifier.volume61en_US
dc.identifier.issue3en_US
dc.identifier.startpage582-
dc.identifier.startpage582en_US
dc.identifier.endpage585en_US
dc.authorid0000-0003-0012-4700-
dc.authorid0000-0003-4575-5653-
dc.authorid0000-0002-2570-3445-
dc.identifier.doi10.2310/JIM.0b013e3182823390-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid23360845en_US
dc.identifier.scopus2-s2.0-84877896760en_US
dc.identifier.wosWOS:000315462800014en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.grantfulltextnone-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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