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https://hdl.handle.net/11499/8318
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Senarisoy, M. | - |
dc.contributor.author | Canturk, P. | - |
dc.contributor.author | Zencir, Sevil | - |
dc.contributor.author | Baran, Y. | - |
dc.contributor.author | Topcu, Z. | - |
dc.date.accessioned | 2019-08-16T12:38:32Z | |
dc.date.available | 2019-08-16T12:38:32Z | |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1085-9195 | - |
dc.identifier.uri | https://hdl.handle.net/11499/8318 | - |
dc.identifier.uri | https://doi.org/10.1007/s12013-012-9468-5 | - |
dc.description.abstract | A considerable number of agents with chemotherapeutic potentials reported over the past years were shown to interfere with the reactions of DNA topoisomerases, the essential enzymes that regulate conformational changes in DNA topology. Gossypol, a naturally occurring bioactive phytochemical is a chemopreventive agent against various types of cancer cell growth with a reported activity on mammalian topoisomerase II. The compounds targeting topoisomerases vary in their mode of action; class I compounds act by stabilizing covalent topoisomerase-DNA complexes resulting in DNA strand breaks while class II compounds interfere with the catalytic function of topoisomerases without generating strand breaks. In this study, we report Gossypol as the interfering agent with type I topoisomerases as well. We also carried out an extensive set of assays to analyze the type of interference manifested by Gossypol on DNA topoisomerases. Our results strongly suggest that Gossypol is a potential class II inhibitor as it blocked DNA topoisomerase reactions with no consequently formed strand breaks. © 2012 Springer Science+Business Media New York. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Cell Biochemistry and Biophysics | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Anticancer drug research | en_US |
dc.subject | DNA strand breaks | en_US |
dc.subject | DNA topoisomerases | en_US |
dc.subject | Gossypol | en_US |
dc.subject | DNA topoisomerase | en_US |
dc.subject | DNA topoisomerase (ATP hydrolysing) | en_US |
dc.subject | DNA topoisomerase inhibitor | en_US |
dc.subject | gossypol | en_US |
dc.subject | gyrase inhibitor | en_US |
dc.subject | animal | en_US |
dc.subject | article | en_US |
dc.subject | chemistry | en_US |
dc.subject | DNA strand breakage | en_US |
dc.subject | enzyme activation | en_US |
dc.subject | enzyme assay | en_US |
dc.subject | enzyme stability | en_US |
dc.subject | macromolecule | en_US |
dc.subject | plasmid | en_US |
dc.subject | Animals | en_US |
dc.subject | DNA Breaks | en_US |
dc.subject | DNA Topoisomerases, Type I | en_US |
dc.subject | DNA Topoisomerases, Type II | en_US |
dc.subject | Enzyme Activation | en_US |
dc.subject | Enzyme Assays | en_US |
dc.subject | Enzyme Stability | en_US |
dc.subject | Macromolecular Substances | en_US |
dc.subject | Plasmids | en_US |
dc.subject | Topoisomerase I Inhibitors | en_US |
dc.subject | Topoisomerase II Inhibitors | en_US |
dc.subject | Mammalia | en_US |
dc.title | Gossypol Interferes with Both Type I and Type II Topoisomerase Activities Without Generating Strand Breaks | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 66 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 199 | |
dc.identifier.startpage | 199 | en_US |
dc.identifier.endpage | 204 | en_US |
dc.identifier.doi | 10.1007/s12013-012-9468-5 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 23161103 | en_US |
dc.identifier.scopus | 2-s2.0-84876183776 | en_US |
dc.identifier.wos | WOS:000317860900023 | en_US |
dc.identifier.scopusquality | Q1 | - |
dc.owner | Pamukkale University | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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10.1007 s12013-012-9468-5.pdf | 243.45 kB | Adobe PDF | View/Open |
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