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https://hdl.handle.net/11499/8444
Title: | The Synergistic effect of fotemustine and genistein on expressions of p53, EGFR and COX-2 genes in human glioblastoma multiforme cell line | Other Titles: | Fotemustin ve Genisteinin Glioblastom Multiforme Hücre Hattında p53, EGFR ve COX-2 Genlerinin Ekspresyonları Üzerine Sinerjistik Etkisi | Authors: | Avcı, C.B. Dodurga, Yavuz Oktar, N. Yilmaz Süslüer, S. Doğan Şigva, Z.O. Gündüz, C. |
Keywords: | COX-2 EGFR Fotemustine Genistein p53 U-87MG cyclooxygenase 2 epidermal growth factor receptor fotemustine genistein protein p53 antiproliferative activity article cell viability concentration response controlled study Cox 2 gene cytotoxicity drug effect drug potentiation EGFR gene gene gene expression gene expression profiling glioblastoma glioma cell human human cell IC 50 real time polymerase chain reaction reverse transcription polymerase chain reaction tumor suppressor gene |
Abstract: | GBM is the most common primary malignant neoplasm of the central nervous system in adults. Fotemustine (FTM) is a cytotoxic alkylating agent and a lipophilic chloroethylnitrosourea derivative. Its mechanism of action consists mainly in inducing DNA strand breaks and cross-linking. Genistein, one of the soy-derived isoflavones, exerts its anticancer properties via several mechanisms, including inhibition of tyrosine phosphorylation, weak estrogenic and anti-estrogenic properties, as an antioxidant, inhibition of topoisomerase II, inhibition of angiogenesis, and induction of cell differentiation in a number of human tumors. We aimed to investigate the anti-proliferative synergistic effect of genistein with fotemustine on human glioblastoma multiforme U87-MG cells. This study was also designed to answer the following question: Do the p53, EGFR, COX-2 genes' expression patterns differ in treatment of these both drugs alone and in combination? | URI: | https://hdl.handle.net/11499/8444 | ISSN: | 1300-1817 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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