Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8533
Title: Effects of oriental sweet gum storax on porcinewound healing
Authors: Öçsel, Hakan
Teke, Z.
Sacar, M.
Kabay, Burhan
Düzcan, S.Ender
Gökalan Kara, Bahriye İnci
Keywords: Granulation tissue
Hydrocolloid dressing
Liquidambar orientalis Mill
Oriental sweet gum
Re-epithelialization
Silver sulfadiazine
Storax
Styrax
Wound healing
hydroxyproline
plant extract
storax
sulfadiazine silver
unclassified drug
animal experiment
animal model
animal tissue
article
controlled study
epithelization
granulation tissue
histopathology
hydrocolloid dressing
Liquidambar
Liquidambar orientalis
nonhuman
priority journal
swine
thickness
wound contraction
wound dressing
wound healing
Animals
Colloids
Epithelium
Granulation Tissue
Hydroxyproline
Phytotherapy
Regeneration
Silver Sulfadiazine
Swine
Wound Healing
Abstract: Purpose: The objective of the present study was to assess the effects of oriental sweet gum (Liquidambar orientalis Mill.) storax on partial-thickness and full-thickness wounds compared to conventional wound dressings in a porcine model. Methods: Six young Yorkshire pigs were used. Sixteen square excisional wounds measuring 3 × 3 cm were performed per animal. The wounds were allocated to one of the four treatment modalities: storax, hydrocolloid dressing, silver sulfadiazine, and control groups. Partial-thickness wounds were created in two pigs, and tissue samples were harvested on days 4 and 8, respectively. Full-thickness wounds were created in four pigs, and tissue samples were taken on days 4, 8, 14, and 21, respectively. Histologically, all wounds were examined for re-epithelialization and granulation tissue formation. Tissue hydroxyproline content and wound contraction areas were measured. Results: In storax-applied group, there was a greater depth of granulation tissue at 4 and 8 days compared to all other groups (p < .0125), and there was a faster re-epithelialization at 21 days compared to both hydrocolloid dressing and control groups in full-thickness wounds (p < .0125). Tissue hydroxyproline content and wound contraction did not differ significantly between the groups. Conclusion: The results of this study indicate that topical application of storax enhanced both re-epithelialization and granulation tissue formation in full-thickness wounds. Further studies are indicated in this important area of wound healing research to evaluate the clinical efficacy of this storax and search for the mechanisms that explain its effects. © 2012 Informa Healthcare USA, Inc.
URI: https://hdl.handle.net/11499/8533
https://doi.org/10.3109/08941939.2011.639847
ISSN: 0894-1939
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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