Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8539
Title: Higher expression of the novel gene upregulated gene 4 in two acute lymphoblastic leukemia patients with poor prednisolone response
Authors: Oymak, Y.
Dodurga, Yavuz
Turedi, A.
Yaman, Y.
Ozek, G.
Carti, O.
Gunes, B.T.
Keywords: Acute lymphoblastic leukemia
Leukemogenesis
Poor prednisolone response
URG4
cell marker
chromosome protein
leukocyte antigen
microsomal aminopeptidase
prednisolone
unclassified drug
upregulated gene 4 protein
acute lymphoblastic leukemia
anemia
article
blast cell
bone marrow biopsy
cancer prognosis
case report
cell growth
cell survival
cerebrospinal fluid analysis
child
clinical protocol
cytogenetics
disease free survival
fatigue
female
fever
flow cytometry
fluorescence in situ hybridization
gene expression regulation
hematopoietic stem cell transplantation
high risk patient
human
human cell
human tissue
immunophenotyping
leukemia cell
leukemia remission
leukemogenesis
leukocytosis
lymphocyte
male
pallor
priority journal
reverse transcription polymerase chain reaction
school child
splenomegaly
thrombocytopenia
treatment response
upregulation
weakness
weight reduction
Base Sequence
Child
DNA Primers
Female
Gene Expression Regulation, Neoplastic
Humans
Male
Neoplasm Proteins
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prednisolone
Abstract: Elucidation of the molecular mechanisms of leukemogenesis is important for a better understanding of the prognosis of acute lymphoblastic leukemia (ALL). Studies have shown that the expression of upregulated gene 4 (URG4), which promotes cell growth and survival, is increased in different types of carcinomas including hepatocellular carcinoma, gastric cancer and osteosarcoma. Similarly, higher expression of URG4 and cyclin D1 gene might promote proliferation of the blast cells by causing escape from the G1 checkpoint and entry into the S phase. This study reports the high expression level of URG4 in 2 high-risk ALL patients for the first time in the literature. In conclusion, the higher expression of URG4 in our 2 patients suggests that URG4 might be involved in leukemogenesis. Future studies with a large number of high-risk ALL patients and cell culture studies are needed to demonstrate the exact role of URG4 in leukemogenesis. © 2012 S. Karger AG Basel.
URI: https://hdl.handle.net/11499/8539
https://doi.org/10.1159/000338220
ISSN: 0001-5792
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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