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https://hdl.handle.net/11499/8539
Title: | Higher expression of the novel gene upregulated gene 4 in two acute lymphoblastic leukemia patients with poor prednisolone response | Authors: | Oymak, Y. Dodurga, Yavuz Turedi, A. Yaman, Y. Ozek, G. Carti, O. Gunes, B.T. |
Keywords: | Acute lymphoblastic leukemia Leukemogenesis Poor prednisolone response URG4 cell marker chromosome protein leukocyte antigen microsomal aminopeptidase prednisolone unclassified drug upregulated gene 4 protein acute lymphoblastic leukemia anemia article blast cell bone marrow biopsy cancer prognosis case report cell growth cell survival cerebrospinal fluid analysis child clinical protocol cytogenetics disease free survival fatigue female fever flow cytometry fluorescence in situ hybridization gene expression regulation hematopoietic stem cell transplantation high risk patient human human cell human tissue immunophenotyping leukemia cell leukemia remission leukemogenesis leukocytosis lymphocyte male pallor priority journal reverse transcription polymerase chain reaction school child splenomegaly thrombocytopenia treatment response upregulation weakness weight reduction Base Sequence Child DNA Primers Female Gene Expression Regulation, Neoplastic Humans Male Neoplasm Proteins Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma Prednisolone |
Abstract: | Elucidation of the molecular mechanisms of leukemogenesis is important for a better understanding of the prognosis of acute lymphoblastic leukemia (ALL). Studies have shown that the expression of upregulated gene 4 (URG4), which promotes cell growth and survival, is increased in different types of carcinomas including hepatocellular carcinoma, gastric cancer and osteosarcoma. Similarly, higher expression of URG4 and cyclin D1 gene might promote proliferation of the blast cells by causing escape from the G1 checkpoint and entry into the S phase. This study reports the high expression level of URG4 in 2 high-risk ALL patients for the first time in the literature. In conclusion, the higher expression of URG4 in our 2 patients suggests that URG4 might be involved in leukemogenesis. Future studies with a large number of high-risk ALL patients and cell culture studies are needed to demonstrate the exact role of URG4 in leukemogenesis. © 2012 S. Karger AG Basel. | URI: | https://hdl.handle.net/11499/8539 https://doi.org/10.1159/000338220 |
ISSN: | 0001-5792 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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