Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8540
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dc.contributor.authorYaren, Arzu-
dc.contributor.authorTurgut, Sebahat-
dc.contributor.authorAyada, Ceylan-
dc.contributor.authorAkcılar, Raziye-
dc.contributor.authorDeğirmencioğlu, Serkan-
dc.contributor.authorGököz Doğu, Gamze-
dc.date.accessioned2019-08-16T12:42:08Z
dc.date.available2019-08-16T12:42:08Z
dc.date.issued2012-
dc.identifier.issn0378-1119-
dc.identifier.urihttps://hdl.handle.net/11499/8540-
dc.identifier.urihttps://doi.org/10.1016/j.gene.2012.04.078-
dc.description.abstractWe aimed to assess the association between IGF-I gene (CA repeats) polymorphism in breast cancer patients and their clinicopathological features, as well as disease recurrence and survival. Seventy-six non-metastatic breast cancer patients were enrolled in the present study. The IGF-I (CA) repeats were studied with polymerase chain reaction by using proper primers belonging to these gene areas from DNA samples. Results show that the non 19- non 19 homozygote were more common in patients without lymph node involvement (p = 0.04), with low histological grade (p = 0.04), with positive hormone receptor status (p = 0.01), and in patients without recurrence (p = 0.06). These results suggest that the non 19-non 19 carriers have some favorable prognostic factors, and IGF-I gene polymorphism (CA repeats) may affect disease recurrence and overall survival. © 2012 Elsevier B.V.en_US
dc.language.isoenen_US
dc.relation.ispartofGeneen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast canceren_US
dc.subjectGene polymorphismen_US
dc.subjectInsulin-like growth factoren_US
dc.subjectPrognosisen_US
dc.subjectantineoplastic agenten_US
dc.subjectDNAen_US
dc.subjectinsulin like growth factor 1 proteinen_US
dc.subjectsomatomedinen_US
dc.subjectunclassified drugen_US
dc.subjectadjuvant therapyen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectaxillary lymph nodeen_US
dc.subjectbreast canceren_US
dc.subjectcancer adjuvant therapyen_US
dc.subjectcancer radiotherapyen_US
dc.subjectcancer recurrenceen_US
dc.subjectcancer survivalen_US
dc.subjectclinical featureen_US
dc.subjectDNA polymorphismen_US
dc.subjectfemaleen_US
dc.subjectgenetic analysisen_US
dc.subjecthumanen_US
dc.subjectlymph node dissectionen_US
dc.subjectmajor clinical studyen_US
dc.subjectmastectomyen_US
dc.subjectneoplasmen_US
dc.subjectoverall survivalen_US
dc.subjectpartial mastectomyen_US
dc.subjectpriority journalen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectDisease-Free Survivalen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectInsulin-Like Growth Factor Ien_US
dc.subjectMiddle Ageden_US
dc.subjectNeoplasm Recurrence, Localen_US
dc.subjectPolymorphism, Geneticen_US
dc.titleInsulin-like growth factor I (Igf-1) gene polymorphism in patients with non-metastatic breast canceren_US
dc.typeArticleen_US
dc.identifier.volume503en_US
dc.identifier.issue2en_US
dc.identifier.startpage244
dc.identifier.startpage244en_US
dc.identifier.endpage247en_US
dc.authorid0000-0002-7884-5623-
dc.authorid0000-0002-6272-4173-
dc.authorid0000-0003-4720-1945-
dc.authorid0000-0002-1213-2778-
dc.authorid0000-0001-8142-0362-
dc.identifier.doi10.1016/j.gene.2012.04.078-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid22564703en_US
dc.identifier.scopus2-s2.0-84861823330en_US
dc.identifier.wosWOS:000309249400009en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.languageiso639-1en-
item.fulltextNo Fulltext-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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