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https://hdl.handle.net/11499/8571
Title: | Conjunctival impression cytology, ocular surface and tear-film changes in patients with lichen planus | Authors: | Şanlı, Berna Çetin, Ebru Nevin Bir, Ferda Taşlı, Levent Yaldızkaya, Filiz Yaylalı, Volkan |
Keywords: | article blepharitis clinical article controlled study dry eye fluorescence analysis human human tissue impression cytology lichen planus lissamine green scoring medical parameters ocular surface priority journal Schirmer test scoring system tear film Adult Aged Case-Control Studies Conjunctival Diseases Female Humans Lacrimal Apparatus Diseases Lichen Planus Male Middle Aged Tears Young Adult |
Abstract: | Background. Lichen planus (LP) is an immune-mediated chronic mucocutaneous disease. Rarely, LP affects the conjunctiva, resulting in conjunctival inflammation, cicatrization and scarring of the subepithelium and cornea, causing keratitis and keratoconjunctivitis sicca. To date, there has been no case-control study examining the ocular findings in LP. Aim. To assess ocular surface health and tear-film changes in patients with LP. Methods. In total, 20 patients and 24 healthy controls were enrolled in the study. Ocular surface changes were evaluated by conjunctival impression cytology, while tear-film functions were measured by the Schirmer test, break-up time, and fluorescein and lissamine green scoring. Results. There was a significant difference in Schirmer test results, conjunctival lissamine green staining scores, and conjunctival impression-cytology grades between the groups. Conclusions. LP may cause ocular surface changes and reduction in tear production, therefore it seems reasonable to evaluate these patients for symptoms and signs of dry-eye disease. We consider that LP should be included in the differential diagnosis of dry-eye disease, as this has important therapeutic and prognostic implications. CED © 2012 British Association of Dermatologists. | URI: | https://hdl.handle.net/11499/8571 https://doi.org/10.1111/j.1365-2230.2011.04274.x |
ISSN: | 0307-6938 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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