Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8584
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dc.contributor.authorArslan, İdris-
dc.contributor.authorÇelik, Ali-
dc.contributor.authorChol, J.H.-
dc.date.accessioned2019-08-16T12:42:57Z
dc.date.available2019-08-16T12:42:57Z
dc.date.issued2012-
dc.identifier.issn0367-326X-
dc.identifier.urihttps://hdl.handle.net/11499/8584-
dc.identifier.urihttps://doi.org/10.1016/j.fitote.2012.02.005-
dc.description.abstractA cytotoxic triterpenoid saponin was isolated from the under-ground parts of Gypsophila pilulifera Boiss.& Heldr. (Caryophyllaceae) naturally grow in the southwestern region of the Turkey. The structures of saponin was elucidated as 3-O-ß-d-galactopyranosyl-(1 › 2)-[ß-d-xylopyranosyl-(1 › 3)]-ß-d-glucuronopyranosyl quillaic acid 28-O-ß-d-glucopyranosyl-(1 › 3)-[ß-d-xylopyranosyl-(1 › 4]-?-l-rhamnopyranosyl-(1 › 2)-ß-d-fucopyranosyl ester on the basis of extensive spectral analysis and chemical evidence. The separated triterpenoid saponin was isolated from Gypsophila pilulifera for the first time. The saponin compound displayed significant cytotoxicity against A549 cell line with IC50 values > 16 µM. © 2012 Elsevier B.V. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofFitoterapiaen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectA549en_US
dc.subjectCytotoxicityen_US
dc.subjectGypsophila piluliferaen_US
dc.subjectHPLCen_US
dc.subjectNMRen_US
dc.subjectSaponinen_US
dc.subject3 o beta dextro galactopyranosyl(1-2)[beta dextro xylopyranosyl(1-3)] beta dextro glucopyranosyl quillaic acid 28 o beta dextro glucopyranosyl(1-3)[beta dextro xylopyranosyl(1-4)] alpha levo rhamnopyranosyl(1-2) beta dextro fucopyranosyl esteren_US
dc.subjectcytotoxic agenten_US
dc.subjectsaponin derivativeen_US
dc.subjecttriterpenoiden_US
dc.subjectunclassified drugen_US
dc.subjectarticleen_US
dc.subjectcancer cell cultureen_US
dc.subjectCaryophyllaceaeen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug cytotoxicityen_US
dc.subjectdrug isolationen_US
dc.subjectdrug structureen_US
dc.subjectIC 50en_US
dc.subjectplant rooten_US
dc.subjectpriority journalen_US
dc.subjectstructure analysisen_US
dc.subjectGypsophilaen_US
dc.titleA cytotoxic triterpenoid saponin from under-ground parts of Gypsophila pilulifera Boiss.& Heldr.en_US
dc.typeArticleen_US
dc.identifier.volume83en_US
dc.identifier.issue4en_US
dc.identifier.startpage699
dc.identifier.startpage699en_US
dc.identifier.endpage703en_US
dc.authorid0000-0001-7634-7148-
dc.authorid0000-0001-7396-2671-
dc.identifier.doi10.1016/j.fitote.2012.02.005-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid22391024en_US
dc.identifier.scopus2-s2.0-84861708529en_US
dc.identifier.wosWOS:000304386900011en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
crisitem.author.dept20.03. Biomedical Engineering-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:Fen-Edebiyat Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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