Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8619
Title: A proton magnetic resonance spectroscopy study in schizoaffective disorder: Comparison of bipolar disorder and schziophrenia
Authors: Kalayci, D.
Özdel, Osman İsmail
Sözeri-Varma, Gülfizar
Kıroglu, Yılmaz
Tümkaya, Selim
Keywords: Bipolar disorder
Executive function
Magnetic resonance spectroscopy
Schizoaffective disorder
Schizophrenia
atypical antipsychotic agent
choline
creatine
creatine phosphate
glycerophosphorylcholine
mood stabilizer
n acetylaspartic acid
adult
age
article
attention
bipolar disorder
clinical article
controlled study
disease course
disease duration
drug use
educational status
emotional disorder
executive function
female
human
male
metabolite
prefrontal cortex
proton nuclear magnetic resonance
psychotic symptom
remission
schizoaffective psychosis
schizophrenia
Stroop test
symptom
Wisconsin Card Sorting Test
Adult
Bipolar Disorder
Female
Humans
Magnetic Resonance Spectroscopy
Male
Middle Aged
Neuropsychological Tests
Protons
Psychotic Disorders
Questionnaires
Schizophrenic Psychology
Abstract: The aim of this study was to compare schizoaffective disorder, bipolar disorder and schizophrenia based on 1H-MRS metabolite values in dorsolateral prefrontal cortex and executive functions. The subjects comprised 15 patients with bipolar disorder type I (BD), 15 with schizophrenia (SCH), 15 with schizoaffective disorder (SAD) and 15 healthy controls. We performed proton magnetic resonance spectroscopy ( 1H-MRS) of the dorsolateral prefrontal cortex (DLPFC) bilaterally. Levels of N-acetyl aspartate (NAA), choline-containing compounds (Cho) and creatine-containing compounds (Cr) were measured in the DLPFC using 1H-MRS. We administered the Wisconsin Card Sorting Test (WCST) and the Stroop Test (ST) to evaluate executive functions. The SAD, BD and SCH patients had lower levels of NAA than the control group. The SAD and BD patients had low levels of Cho compared to the control group. The left DLPFC Cr levels in all of the patient groups and the right DLPFC Cr levels in the BD and SAD groups were lower than in the control group. The levels of NAA Cho and Cr were not related to executive functions and attention performance. Cr level were related to attention processes, only in SCH. Our results indicate that NAA levels are reduced in schizoaffective disorder, bipolar disorder and schizophrenia, but the reduction in the levels of NAA is not a distinctive feature among these three illnesses. Schizoaffective and bipolar disorders have similar features related to the levels of compounds containing Cho and Cr. This similarity may be related to these illnesses both having an affective basis. © 2012 Elsevier Inc.
URI: https://hdl.handle.net/11499/8619
https://doi.org/10.1016/j.pnpbp.2012.01.010
ISSN: 0278-5846
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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