Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8642
Title: Penicillin susceptibility of viridans group streptococci isolated from the oropharynx of patients with hematological malignancy
Other Titles: Hematolojik kanserli hastaların orofarinksinden izole edilen viridans grubu streptokoklarda penisilin duyarlılıgı
Authors: Sayın Kutlu, Selda
Ökke, Demet
Demir, Melek
Tepeli, Ebru
Sarı, Hakan İsmail
Keywords: Hematologic neoplasms
Penicillin susceptibility
Viridans streptococci
antibiotic agent
immunosuppressive agent
penicillin G
teicoplanin
alpha hemolytic Streptococcus
antibiotic resistance
article
bacterium culture
bacterium isolation
comorbidity
disease association
disease duration
hematologic malignancy
human
length of stay
minimum inhibitory concentration
nonhuman
pharyngitis
prospective study
risk assessment
smoking habit
Streptococcus viridans infection
Abstract: Objective: The objective of this study is to determine the susceptibility to penicillin and teicoplanin of viridans group streptococci (VGS) isolated from the oropharynx of patients with hematological malignancies and to assess the risk factors for penicillin resistance. Methods: This prospective cohort study was conducted between January 2007 and December 2008 in patients with hematological malignancies. Oropharyngeal cultures were obtained and risk factors for reduced susceptibility to penicillin of VGS were analyzed. Results: VGS were isolated from the oropharynx in 75 of 122 patients. Penicillin minimum inhibitor concentration (MIC) range was 0.047-3.0 mg/L. Thirty-two (42.7%) isolates were susceptible to penicillin. High-level penicillin resistance (MIC ?4 mg/L) was determined in none of the isolates. However, 43 (57.3%) of the isolates had reduced susceptibility to penicillin. Teicoplanin MIC range was 0.047-0.94 mg/L. Type and duration of hematological malignancy, presence of comorbidities, previous hospitalization within a year, length of hospital stay, antibiotic use within the previous six months, immunosuppressive drugs, and smoking were not a risk factor for reduced susceptibility to penicillin. Conclusions: The determination of antibiotic susceptibility of VGS in the oropharyngeal flora has significant implications for empirical therapy of the infections in patients with hematological malignancies. It is important to design larger studies to determine a therapeutic guideline based on local data for patients with hematological malignancies.
URI: https://hdl.handle.net/11499/8642
https://doi.org/10.5152/kd.2012.03
ISSN: 1301-143X
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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