Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8648
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dc.contributor.authorKortunay, Selim-
dc.contributor.authorErken, H.A.-
dc.contributor.authorErken, G.-
dc.contributor.authorGenç, O.-
dc.contributor.authorŞahiner, M.-
dc.contributor.authorTurgut, Sebahat-
dc.contributor.authorTurgut, Günfer-
dc.date.accessioned2019-08-16T12:44:14Z
dc.date.available2019-08-16T12:44:14Z
dc.date.issued2012-
dc.identifier.isbn01969781 (ISSN)-
dc.identifier.urihttps://hdl.handle.net/11499/8648-
dc.identifier.urihttps://doi.org/10.1016/j.peptides.2012.02.013-
dc.description.abstractOrexins have been implicated with physiological function including sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on excitability are controversial. We investigated the effects of intracortical injections of orexin A (100 pmol) and B (100 pmol) on the electrophysiological manifestation of epileptic seizures induced by cortical penicillin application in adult male rats. In comparison to saline, orexin A and B enhanced significantly the spike number, spike amplitude and spectral power values induced by cortical penicillin. Our findings indicates that orexins enhances the hyperexcitable and hypersyncronic cortical epileptic activity induced by focal application of penicillin-G. © 2012 Elsevier Inc. All rights reserved.en_US
dc.language.isoenen_US
dc.relation.ispartofPeptidesen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEEGen_US
dc.subjectEpilepsyen_US
dc.subjectOrexinen_US
dc.subjectPenicillinen_US
dc.subjectPower spectrumen_US
dc.subjectSeizureen_US
dc.subjectorexin Aen_US
dc.subjectorexin Ben_US
dc.subjectpenicillin Gen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectarticleen_US
dc.subjectbrain electrophysiologyen_US
dc.subjectcontrolled studyen_US
dc.subjectepileptic dischargeen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectpriority journalen_US
dc.subjectraten_US
dc.subjectspikeen_US
dc.subjectAnimalsen_US
dc.subjectBehavior, Animalen_US
dc.subjectCerebral Cortexen_US
dc.subjectElectroencephalographyen_US
dc.subjectInfusions, Intraventricularen_US
dc.subjectIntracellular Signaling Peptides and Proteinsen_US
dc.subjectMaleen_US
dc.subjectNeuropeptidesen_US
dc.subjectNeurotransmitter Agentsen_US
dc.subjectPenicillin Gen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.subjectRattusen_US
dc.titleOrexins increase penicillin-induced epileptic activityen_US
dc.typeArticleen_US
dc.identifier.volume34en_US
dc.identifier.issue2en_US
dc.identifier.startpage419
dc.identifier.startpage419en_US
dc.identifier.endpage422en_US
dc.authorid0000-0002-7884-5623-
dc.identifier.doi10.1016/j.peptides.2012.02.013-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid22394654en_US
dc.identifier.scopus2-s2.0-84859432223en_US
dc.identifier.wosWOS:000303181600020en_US
dc.ownerPamukkale University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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