Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8675
Title: Effects of quercetin induced cell death on a novel gene "URG4/URGCP" expression in leukemia cells
Authors: Dodurga, Yavuz
Avci, C.B.
Şatıroğlu-Tufan, Naciye Lale
Susluer, S.Y.
Sigva, O.D.Z.
Saydam, G.
Gunduz, Cumhur
Keywords: Leukemia cells
Quercetin
Urg4/urgcp
molecular marker
quercetin
antiproliferative activity
apoptosis
article
cell strain K 562
controlled study
gene
gene expression regulation
human
human cell
IC 50
leukemia cell
prediction
prognosis
reverse transcription polymerase chain reaction
upregulated gene 4
Abstract: The present study aimed to investigate anti-proliferative and apoptotic effects of quercetin on human leukemia cells and effects of quercetin-induced cell death on a novel gene Up-regulated gene 4/upregulator of cell proliferation (URG4/URGCP), in leukemia cells. URG4/URGCP expression is determined by using RT-PCR. IC 50 of quercetin was determined as 25 microM in CCRF-CEM, HL-60 and K562 cells. In IC 50 dose group, URG4/URGCP expression was decreased 99% in HL-60 cells, 90% in CCRF-CEM cells, and 52% (24 hour) - 99% (72 hour) in K-562 cells. URG4/URGCP may play important roles in the development of leukemia, and might be a useful molecular marker for predicting the prognosis of leukemia via quercetin treatment. © 2012 Dodurga Y, et al.
URI: https://hdl.handle.net/11499/8675
https://doi.org/10.4172/1948-5956.1000102
ISSN: 1948-5956
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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