Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8675
Title: Effects of quercetin induced cell death on a novel gene "URG4/URGCP" expression in leukemia cells
Authors: Dodurga, Yavuz
Avci, C.B.
Şatıroğlu-Tufan, Naciye Lale
Susluer, S.Y.
Sigva, O.D.Z.
Saydam, G.
Gunduz, C.
Keywords: Leukemia cells
Quercetin
Urg4/urgcp
molecular marker
quercetin
antiproliferative activity
apoptosis
article
cell strain K 562
controlled study
gene
gene expression regulation
human
human cell
IC 50
leukemia cell
prediction
prognosis
reverse transcription polymerase chain reaction
upregulated gene 4
Abstract: The present study aimed to investigate anti-proliferative and apoptotic effects of quercetin on human leukemia cells and effects of quercetin-induced cell death on a novel gene Up-regulated gene 4/upregulator of cell proliferation (URG4/URGCP), in leukemia cells. URG4/URGCP expression is determined by using RT-PCR. IC 50 of quercetin was determined as 25 microM in CCRF-CEM, HL-60 and K562 cells. In IC 50 dose group, URG4/URGCP expression was decreased 99% in HL-60 cells, 90% in CCRF-CEM cells, and 52% (24 hour) - 99% (72 hour) in K-562 cells. URG4/URGCP may play important roles in the development of leukemia, and might be a useful molecular marker for predicting the prognosis of leukemia via quercetin treatment. © 2012 Dodurga Y, et al.
URI: https://hdl.handle.net/11499/8675
https://doi.org/10.4172/1948-5956.1000102
ISSN: 1948-5956
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

Files in This Item:
File SizeFormat 
10.4172 1948-5956.1000102.pdf1.65 MBAdobe PDFView/Open
Show full item record



CORE Recommender

SCOPUSTM   
Citations

1
checked on Nov 16, 2024

Page view(s)

96
checked on Aug 24, 2024

Download(s)

90
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.