Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8675
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dc.contributor.authorDodurga, Yavuz-
dc.contributor.authorAvci, C.B.-
dc.contributor.authorŞatıroğlu-Tufan, Naciye Lale-
dc.contributor.authorSusluer, S.Y.-
dc.contributor.authorSigva, O.D.Z.-
dc.contributor.authorSaydam, G.-
dc.contributor.authorGunduz, Cumhur-
dc.date.accessioned2019-08-16T12:44:45Z-
dc.date.available2019-08-16T12:44:45Z-
dc.date.issued2012-
dc.identifier.issn1948-5956-
dc.identifier.urihttps://hdl.handle.net/11499/8675-
dc.identifier.urihttps://doi.org/10.4172/1948-5956.1000102-
dc.description.abstractThe present study aimed to investigate anti-proliferative and apoptotic effects of quercetin on human leukemia cells and effects of quercetin-induced cell death on a novel gene Up-regulated gene 4/upregulator of cell proliferation (URG4/URGCP), in leukemia cells. URG4/URGCP expression is determined by using RT-PCR. IC 50 of quercetin was determined as 25 microM in CCRF-CEM, HL-60 and K562 cells. In IC 50 dose group, URG4/URGCP expression was decreased 99% in HL-60 cells, 90% in CCRF-CEM cells, and 52% (24 hour) - 99% (72 hour) in K-562 cells. URG4/URGCP may play important roles in the development of leukemia, and might be a useful molecular marker for predicting the prognosis of leukemia via quercetin treatment. © 2012 Dodurga Y, et al.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Cancer Science and Therapyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLeukemia cellsen_US
dc.subjectQuercetinen_US
dc.subjectUrg4/urgcpen_US
dc.subjectmolecular markeren_US
dc.subjectquercetinen_US
dc.subjectantiproliferative activityen_US
dc.subjectapoptosisen_US
dc.subjectarticleen_US
dc.subjectcell strain K 562en_US
dc.subjectcontrolled studyen_US
dc.subjectgeneen_US
dc.subjectgene expression regulationen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectIC 50en_US
dc.subjectleukemia cellen_US
dc.subjectpredictionen_US
dc.subjectprognosisen_US
dc.subjectreverse transcription polymerase chain reactionen_US
dc.subjectupregulated gene 4en_US
dc.titleEffects of quercetin induced cell death on a novel gene "URG4/URGCP" expression in leukemia cellsen_US
dc.typeArticleen_US
dc.identifier.volume4en_US
dc.identifier.issue1en_US
dc.identifier.startpage6-
dc.identifier.startpage6en_US
dc.identifier.endpage9en_US
dc.authorid0000-0002-4936-5954-
dc.authorid0000-0001-9399-0960-
dc.identifier.doi10.4172/1948-5956.1000102-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-84857299483en_US
dc.identifier.scopusqualityQ3-
dc.ownerPamukkale University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
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