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https://hdl.handle.net/11499/8688
Title: | Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey | Authors: | Sahin, Z. Bicakcigil, M. Aksu, K. Kamali, S. Akar, S. Onen, F. Karadag, O. |
Keywords: | DNA HLA B51 antigen HLA B52 antigen adult age aorta arch syndrome article controlled study disease association disease severity DNA determination female gene sequence genetic screening genetic susceptibility human major clinical study male multicenter study polymerase chain reaction Turkey (republic) case control study chi square distribution gene frequency genetic predisposition genetics genotype middle aged risk Adult Case-Control Studies Chi-Square Distribution Female Gene Frequency Genetic Predisposition to Disease Genotype HLA-B51 Antigen HLA-B52 Antigen Humans Male Middle Aged Odds Ratio Takayasu Arteritis Turkey |
Abstract: | Introduction: HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) allele groups with minor amino acid differences. However, they are associated with two different vasculitides (HLA-B*51 in Behçet's disease and HLA-B*52 in Takayasu's arteritis (TAK)) and with major clinical and immunological differences. In this study, we aimed to screen a large cohort of TAK patients from Turkey for the presence of HLA-B*51 and HLA-B*52 as susceptibility and severity factors.Methods: TAK patients (n = 330) followed at a total of 15 centers were included in the study. The mean age of the patients was 37.8 years, and 86% were women. DNA samples from the patients and healthy controls (HC; n = 210) were isolated, and the presence of HLA-B*51 or HLA-B*52 was screened for by using PCR with sequence-specific primers.Results: We found a significant association of HLA-B*52 with TAK (20.9% vs HC = 6.7%, P = 0.000, OR = 3.7, 95% CI = 2.02 to 6.77). The distribution of HLA-B*51 did not differ between TAK patients and HCs (22.7% vs 24.8%, OR = 0.9, 95% CI = 0.60 to 1.34). The presence of HLA-B*52 decreased in late-onset patients (> 40 years of age; 12.0%, P = 0.024, OR = 0.43, 95% CI = 0.20 to 0.91). Patients with angiographic type I disease with limited aortic involvement also had a lower presence of HLA-B*52 compared to those with all other disease subtypes (13.1% vs 26%, P = 0.005, OR = 0.43, 95% CI = 0.23 to 0.78).Conclusions: In this study, the previously reported association of TAK with HLA-B*52 in other populations was confirmed in patients from Turkey. The functional relevance of HLA-B*52 in TAK pathogenesis needs to be explored further. © 2012 Sahin et al.; licensee BioMed Central Ltd. | URI: | https://hdl.handle.net/11499/8688 https://doi.org/10.1186/ar3730 |
ISSN: | 1478-6354 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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