Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8688
Title: Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey
Authors: Sahin, Z.
Bicakcigil, M.
Aksu, K.
Kamali, S.
Akar, S.
Onen, F.
Karadag, O.
Keywords: DNA
HLA B51 antigen
HLA B52 antigen
adult
age
aorta arch syndrome
article
controlled study
disease association
disease severity
DNA determination
female
gene sequence
genetic screening
genetic susceptibility
human
major clinical study
male
multicenter study
polymerase chain reaction
Turkey (republic)
case control study
chi square distribution
gene frequency
genetic predisposition
genetics
genotype
middle aged
risk
Adult
Case-Control Studies
Chi-Square Distribution
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
HLA-B51 Antigen
HLA-B52 Antigen
Humans
Male
Middle Aged
Odds Ratio
Takayasu Arteritis
Turkey
Abstract: Introduction: HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) allele groups with minor amino acid differences. However, they are associated with two different vasculitides (HLA-B*51 in Behçet's disease and HLA-B*52 in Takayasu's arteritis (TAK)) and with major clinical and immunological differences. In this study, we aimed to screen a large cohort of TAK patients from Turkey for the presence of HLA-B*51 and HLA-B*52 as susceptibility and severity factors.Methods: TAK patients (n = 330) followed at a total of 15 centers were included in the study. The mean age of the patients was 37.8 years, and 86% were women. DNA samples from the patients and healthy controls (HC; n = 210) were isolated, and the presence of HLA-B*51 or HLA-B*52 was screened for by using PCR with sequence-specific primers.Results: We found a significant association of HLA-B*52 with TAK (20.9% vs HC = 6.7%, P = 0.000, OR = 3.7, 95% CI = 2.02 to 6.77). The distribution of HLA-B*51 did not differ between TAK patients and HCs (22.7% vs 24.8%, OR = 0.9, 95% CI = 0.60 to 1.34). The presence of HLA-B*52 decreased in late-onset patients (> 40 years of age; 12.0%, P = 0.024, OR = 0.43, 95% CI = 0.20 to 0.91). Patients with angiographic type I disease with limited aortic involvement also had a lower presence of HLA-B*52 compared to those with all other disease subtypes (13.1% vs 26%, P = 0.005, OR = 0.43, 95% CI = 0.23 to 0.78).Conclusions: In this study, the previously reported association of TAK with HLA-B*52 in other populations was confirmed in patients from Turkey. The functional relevance of HLA-B*52 in TAK pathogenesis needs to be explored further. © 2012 Sahin et al.; licensee BioMed Central Ltd.
URI: https://hdl.handle.net/11499/8688
https://doi.org/10.1186/ar3730
ISSN: 1478-6354
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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