A child case of acute brucellosis presenting with coombs-positive autoimmune hemolytic anemia. Case report

Abstract

Human brucellosis is a multisystem disease with a wide spectrum of clinical manifestations. Brucellosis can mimic several primary hematological diseases. Several non-specific hematologic abnormalities have been reported with brucellosis including anemia, leukopenia, thrombocytopenia and pancytopenia. We discussed about steroid therapy and described a child case of acute brucellosis presenting with Coombs-positive AIHA. A 3.5-year-old girl was admitted to our hospital by pallor, palpitation, fever , scleral icterus. Laboratory test showed hemoglobin 7.4 g/dL, direct Coombs IgG plus C3d test strongly positive (3+). Serology for Brucella was strongly positive (Wright agglutination reaction [1/2560], coombs agglutination reaction [1/5120]). The differential diagnosis child of Coombs-positive AIHA should include brucellosis, especially in patients living in endemic areas.Early diagnosis and treatment of disease at AIHA depentdent brucellos is important because of they could be determined to severe acute hemolysis.