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https://hdl.handle.net/11499/8693
Title: | Is short course of antimicrobial therapy for asymptomatic bacteriuria before urologic surgical procedures sufficient? | Authors: | Kutlu, Selda Sayın Aybek, Zafer Tekin, K. Okke, D. Akalin, S. Altintas, S. Demir, Melek |
Keywords: | Antimicrobial Bacteriuria Urologic surgical procedures antibiotic agent imipenem Acinetobacter baumannii adult antibiotic sensitivity antibiotic therapy article bacteriuria Candida tropicalis clinical article drug cost drug efficacy Escherichia coli extracorporeal lithotripsy female hospitalization human Klebsiella pneumoniae length of stay male medical record review nephrostomy Pseudomonas aeruginosa retrospective study sepsis transurethral resection treatment duration urinary catheter urologic surgery Adult Aged Aged, 80 and over Anti-Infective Agents Female Humans Male Microbial Sensitivity Tests Middle Aged Preoperative Care Sepsis Time Factors Treatment Outcome Urologic Surgical Procedures |
Abstract: | Introduction: Duration of treatment of asymptomatic bacteriuria for patients undergoing urologic surgical procedures is undetermined. We compared the efficacy of long- versus short-course antimicrobial treatment in patients with asymptomatic bacteriuria undergoing urologic surgical procedures. Methodology: Patients were divided into two groups according to duration of antimicrobial treatment. Group A patients received a single dose of an appropriate antibiotic, determined by antimicrobial sensitivity testing, 30 to 60 minutes before the surgical procedure. If a urinary catheter was placed postoperatively, a second dose was given following the recommended dose interval. Group B patients received antimicrobial treatment prior to surgery at least until patient urine became sterile. All patients were monitored for signs and symptoms of septicemia following surgical procedures. Results: None of the patients enrolled in the study developed infectious complications such as sepsis or upper urinary tract infection. In group A, 31 patients were treated with antimicrobials before 39 urological procedures. In group B, the mean treatment time for 28 patients before 30 urological procedures was 8.03 ± 3.86 days. There were also significant differences in length of stay and the cost of antimicrobial therapy between the groups (P < 0.0001). Isolation of an increased number of resistant microorganisms was associated with long course therapy in group B. Conclusions: Short course therapy protocol may be a practical, simple approach for antibiotic use; it decreases hospital stays, eliminates delayed procedure times, lowers the economic cost of antimicrobials and lessens the chance of superinfection with and spread of antimicrobial resistant microorganisms. © 2012 Sayin Kutlu et al. | URI: | https://hdl.handle.net/11499/8693 | ISSN: | 2036-6590 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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