Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8701
Title: Slow infusion metoclopramide does not affect the improvement rate of nausea while reducing akathisia and sedation incidence
Authors: Tura, Pınar
Erdur, Bülent
Aydın, Berrin
Türkçüer, İbrahim
Parlak, I.
Keywords: metoclopramide
midazolam
placebo
sodium chloride
adult
aged
akathisia
article
clinical observation
controlled study
disease severity
double blind procedure
drug effect
emergency patient
emergency ward
female
follow up
human
incidence
infusion rate
major clinical study
male
nausea
priority journal
prospective study
randomized controlled trial
sedation
therapy effect
university
visual analog scale
vital sign
Adult
Akathisia, Drug-Induced
Antiemetics
Deep Sedation
Double-Blind Method
Female
Humans
Infusions, Intravenous
Male
Metoclopramide
Middle Aged
Nausea
Prospective Studies
Young Adult
Abstract: Objective: To compare the effects of metoclopramide infusion in emergency department (ED) patients complaining of nausea to determine the changes in its therapeutic effect and prevention of side effects such as akathisia and sedation. Methods: A prospective, randomised, double blind trial, from 1 March 2007 to 1 May 2008 in the ED of Pamukkale University Faculty of Medicine. Patients with moderate to severe nausea were randomised and divided into two groups: group 1 received 10 mg metoclopramide as a slow intravenous infusion over 15 min plus placebo (SIG); group 2 received 10 mg metoclopramide as an intravenous bolus infusion over 2 min plus placebo (BIG). The whole procedure was observed, and nausea scores, akathisia and vital changes were recorded. Results: 140 patients suffering from moderate to severe nausea in the ED were included in the study. There was no significant difference between the groups in terms of mean nausea scores during follow-up (p=0.97). A significant difference in akathisia incidence was observed between the groups (18 (26.1%) in the BIG and 5 (7%) in the SIG) (p=0.002). There was also a significant difference in sedation incidence between the groups (19 (27.5%) in the BIG and 10 (14.5%) in the SIG) (p=0.05). Conclusion: Even though slowing the rate of infusion of metoclopramide does not affect the rate of improvement in nausea, it may be an effective strategy for reducing the incidence of akathisia and sedation in patients with nausea.
URI: https://hdl.handle.net/11499/8701
https://doi.org/10.1136/emj.2010.094367
ISSN: 1472-0205
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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