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https://hdl.handle.net/11499/8701
Title: | Slow infusion metoclopramide does not affect the improvement rate of nausea while reducing akathisia and sedation incidence | Authors: | Tura, Pınar Erdur, Bülent Aydın, Berrin Türkçüer, İbrahim Parlak, I. |
Keywords: | metoclopramide midazolam placebo sodium chloride adult aged akathisia article clinical observation controlled study disease severity double blind procedure drug effect emergency patient emergency ward female follow up human incidence infusion rate major clinical study male nausea priority journal prospective study randomized controlled trial sedation therapy effect university visual analog scale vital sign Adult Akathisia, Drug-Induced Antiemetics Deep Sedation Double-Blind Method Female Humans Infusions, Intravenous Male Metoclopramide Middle Aged Nausea Prospective Studies Young Adult |
Abstract: | Objective: To compare the effects of metoclopramide infusion in emergency department (ED) patients complaining of nausea to determine the changes in its therapeutic effect and prevention of side effects such as akathisia and sedation. Methods: A prospective, randomised, double blind trial, from 1 March 2007 to 1 May 2008 in the ED of Pamukkale University Faculty of Medicine. Patients with moderate to severe nausea were randomised and divided into two groups: group 1 received 10 mg metoclopramide as a slow intravenous infusion over 15 min plus placebo (SIG); group 2 received 10 mg metoclopramide as an intravenous bolus infusion over 2 min plus placebo (BIG). The whole procedure was observed, and nausea scores, akathisia and vital changes were recorded. Results: 140 patients suffering from moderate to severe nausea in the ED were included in the study. There was no significant difference between the groups in terms of mean nausea scores during follow-up (p=0.97). A significant difference in akathisia incidence was observed between the groups (18 (26.1%) in the BIG and 5 (7%) in the SIG) (p=0.002). There was also a significant difference in sedation incidence between the groups (19 (27.5%) in the BIG and 10 (14.5%) in the SIG) (p=0.05). Conclusion: Even though slowing the rate of infusion of metoclopramide does not affect the rate of improvement in nausea, it may be an effective strategy for reducing the incidence of akathisia and sedation in patients with nausea. | URI: | https://hdl.handle.net/11499/8701 https://doi.org/10.1136/emj.2010.094367 |
ISSN: | 1472-0205 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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