Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8730
Title: The growth hormone receptor polymorphism in patients with acromegaly: Relationship to BMI and glucose metabolism
Authors: Turgut, Sebahat
Akın, Fulya
Ayada, Ceylan
Topsakal, Şenay
Yerlikaya, Emrah
Turgut, Günfer
Keywords: Acromegaly
BMI
d3GHR polymorphism
IGF-I
Insulin
glitazone derivative
glucose
growth hormone
growth hormone receptor
high density lipoprotein cholesterol
insulin
low density lipoprotein cholesterol
metformin
somatomedin binding protein 3
somatomedin C
somatostatin derivative
triacylglycerol
acromegaly
adult
allele
article
blood sampling
body mass
clinical article
diastolic blood pressure
disease association
DNA polymorphism
female
genetic risk
genotype
glucose blood level
glucose metabolism
heterozygote
homozygote
human
insulin resistance
male
polymerase chain reaction
prevalence
priority journal
systolic blood pressure
Publisher: Springer New York LLC
Abstract: The aim of this study was to investigate association between the frequencies of Growth Hormone receptor (d3GHR) gene polymorphisms and some clinical parameters of acromegalic patients. Total of 35 acromegalic patients were enrolled to study. The d3GHR polymorphism was identified by using polymerase chain reaction from peripheral blood samples. The levels of systolic and diastolic blood pressure, BMI, fasting plasma glucose (FPG), Fasting insulin, HOMA-IR, IGF-I, GH, IGFBP3, triglyceride, HDL and LDL cholesterol concentrations were evaluated. The frequencies of d3GHR genotypes were found as follows; 5 (14.3%) subjects had d3/d3, 11 (31.4%) had d3/fl and 19 (54.3%) had fl/fl in patients. The prevalence of the d3 and fl alleles was 30 and 70%, respectively. Systolic blood pressure, fasting insulin and HOMA-IR was found significantly increased in homozygote d3GHR genotype group compared to d3/fl subjects (P\0.05). In addition, BMI was observed significantly different among three genotypes (P = 0.007) and in the subjects with d3/d3 genotype, BMI was found significantly higher than d3/fl and fl/fl genotypes groups. As well as, no significant difference was found between the d3 and fl alleles group in terms of the clinical parameters except for BMI (P = 0.002). It can be said that the d3GHR gene polymorphism may affect BMI, systolic blood pressure and insulin regulation. At the same time we can say homozygote d3GHR genotype and d3 allele carriers may have more risk than other genotypes for high BMI. © Springer Science+Business Media, LLC 2011.
URI: https://hdl.handle.net/11499/8730
https://doi.org/10.1007/s11102-011-0329-9
ISSN: 1386-341X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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