Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/8744
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oguz, Emin Oğuzhan | - |
dc.contributor.author | Enli, Yaşar | - |
dc.contributor.author | Şahin, Barbaros | - |
dc.contributor.author | Gönen, Cafer | - |
dc.contributor.author | Turgut, Günfer | - |
dc.date.accessioned | 2019-08-16T12:46:16Z | |
dc.date.available | 2019-08-16T12:46:16Z | |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1234-1010 | - |
dc.identifier.uri | https://hdl.handle.net/11499/8744 | - |
dc.identifier.uri | https://doi.org/10.12659/MSM.882515 | - |
dc.description.abstract | Background: Aluminium (Al) is known to have neurotoxic effects that can result in oxidative damage to a range of cellular biomolecules. These effects appear to be of significance in the developmental stages of the brain. We therefore investigated the oxidative and histopathological damage induced by Al during growth and development of the chick brain. Material/Methods: We used a chick embryonic development model, with Al treatment of 500 µg Al sulphate in 0.1 ml saline injected into the egg air chambers at the beginning of their incubation period. The effects on chick-brain growth and development were then assessed at term (day 21). Determination of malondialdehyde and glutathione levels were used as relevant biological measures for increased oxidative stress in terms of lipid peroxidation and biochemical oxidative damage, respectively. Furthermore, we also monitored neuronal degeneration as estimated stereologically using the Cavalieri brain volume estimation tool. Results: This Al treatment showed significantly increased MDA levels and decreased GSH levels, as indicators of increased biochemical oxidative damage. This was accompanied by significantly decreased brain volume, as a measure of neuronal degeneration during brain development in this chick embryonic development model. Conclusions: Exposure to Al during chick embryonic development results in increased oxidative stress in the brain that is accompanied by neuronal degeneration. © Med Sci Monit, 2012. | en_US |
dc.language.iso | en | en_US |
dc.publisher | International Scientific Literature Inc. | en_US |
dc.relation.ispartof | Medical Science Monitor | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Aluminium | en_US |
dc.subject | Brain development | en_US |
dc.subject | Cavalieri brain volume estimation | en_US |
dc.subject | Glutathione | en_US |
dc.subject | Malondialdehyde | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | aluminum sulfate | en_US |
dc.subject | glutathione | en_US |
dc.subject | malonaldehyde | en_US |
dc.subject | article | en_US |
dc.subject | brain development | en_US |
dc.subject | brain growth | en_US |
dc.subject | chick | en_US |
dc.subject | controlled study | en_US |
dc.subject | egg | en_US |
dc.subject | embryo development | en_US |
dc.subject | incubation time | en_US |
dc.subject | lipid peroxidation | en_US |
dc.subject | nerve cell degeneration | en_US |
dc.subject | nonhuman | en_US |
dc.subject | oxidative stress | en_US |
dc.title | Aluminium sulphate exposure increases oxidative stress and suppresses brain development in ross broiler chicks | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | BR103 | |
dc.identifier.startpage | BR103 | en_US |
dc.identifier.endpage | BR108 | en_US |
dc.authorid | 0000-0001-5080-3192 | - |
dc.identifier.doi | 10.12659/MSM.882515 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 22367119 | en_US |
dc.identifier.scopus | 2-s2.0-84857810456 | en_US |
dc.identifier.wos | WOS:000302115000004 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale University | - |
item.grantfulltext | open | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 01.01. Experimental Surgical Application and Research Center | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | Acıpayam Meslek Yüksekokulu Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
10.12659 MSM.882515.pdf | 161.12 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
13
checked on Aug 17, 2024
WEB OF SCIENCETM
Citations
9
checked on Jul 31, 2024
Page view(s)
62
checked on Aug 24, 2024
Download(s)
34
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.