Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8775
Title: Prevalence and risk factors for methicillin-resistant Staphylococcus aureus colonization among outpatients undergoing hemodialysis treatment
Authors: Köseoglu, Özlem
Kutlu, Selda Sayın
Cevahir, Nural
Keywords: Hemodialysis
Methicillin-resistant staphylococcus aureus
Nasal colonization
Risk factors
antiinfective agent
adolescent
adult
aged
article
chronic obstructive lung disease
drug effect
female
hospitalization
human
isolation and purification
male
methicillin resistant Staphylococcus aureus
microbiology
middle aged
multidrug resistance
multivariate analysis
nose mucosa
outpatient
prevalence
renal replacement therapy
risk factor
Staphylococcus infection
Turkey (republic)
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents
Drug Resistance, Multiple, Bacterial
Female
Hospitalization
Humans
Male
Methicillin-Resistant Staphylococcus aureus
Middle Aged
Multivariate Analysis
Nasal Mucosa
Outpatients
Prevalence
Pulmonary Disease, Chronic Obstructive
Renal Dialysis
Risk Factors
Staphylococcal Infections
Turkey
Young Adult
Abstract: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) is frequent among hemodialysis patients and lead to increased morbidity and mortality rates. It is known that nasal colonization plays an important role for the development of MRSA infections. The aim of this study was to determine the prevalence and risk factors for MRSA colonization among outpatients undergoing hemodialysis. A total of 466 adult patients (199 female, 267 male; age range: 18-89 years, mean age: 55.8 ± 15.1 years) who were under hemodialysis between September-December 2008 in different health centers at Pamukkale/ Denizli region, Turkey, were included in the study. Swab samples obtained from anterior nares of patients were cultivated on sheep-blood agar and mannitol-salt agar media. The isolates were identified by conventional bacteriological methods. S.aureus strains were isolated from 204 (43.8%) patients and 34 (16.7%) were found methicillin-resistant. Thus the rate of MRSA colonization in hemodialysis patients was detected as 7.3% (34/466). All of the MRSA strains'were found susceptible to vancomycin, linezolid and tigecycline, while the resistance rates for the other antimicrobial agents were as follows: 70.6% to azithromycin and claritromycin; 64.7% to erythromycin; %58.8 to clindamycin, gentamicin and trimethoprim-sulfamethoxazole; 55.9% to ciprofloxacin; 44.1% to tetracycline and rifampin; 5.9% to chloramphenicol. Inducible clindamycin resistance in MRSA isolates was %23.5 (8/34), and multidrug resistance rate was 76.5% (26/34). Multivariate analysis revealed that the history of previous hospitalization within a year [odds ratio (OR), 3.426; 95% confidence interval (CI), 1.595-7.361, p= 0.002] and the presence of chronic obstructive lung disease (OR, 5.181; 95% CI, 1.612-16.648, p= 0.006) were independent risk factors for MRSA colonization in this population. A better understanding of the prevalence and risk factors for nasal MRSA colonization among hemodialysis population may hold significant implications for both the treatment strategies and prevention of MRSA infections to establish appropriate infection control measures.
URI: https://hdl.handle.net/11499/8775
ISSN: 0374-9096
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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