Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/8794
Title: | Vitamin e treatment enhances erythrocyte deformability in aged rats | Authors: | Küçükatay, Vural Bor-Küçükatay, Melek Gündoğdu, Gülşah Erken, G. Özcan, Tonguç Olgun Miloglu, F.D. Kadioglu, Y. |
Keywords: | Aging Haemorheology Oxidative stress Red blood cell aggregation Red blood cell deformability alpha tocopherol antioxidant aging animal experiment article controlled study drug effect erythrocyte aggregation erythrocyte deformability hematological parameters male nonhuman oxidative stress index plasma viscosity rat total antioxidant status total oxidant status animal blood rheology erythrocyte human oxidative stress physiology treatment outcome Wistar rat Animals Antioxidants Erythrocyte Deformability Erythrocytes Hemorheology Humans Male Oxidative Stress Rats Rats, Wistar Treatment Outcome Vitamin E |
Publisher: | Charles University | Abstract: | The harmful effects of aging on blood rheology have been well known. These effects in the aging have been found to be associated with an increase in oxidative stress. The aim of this study was to seek whether treatment of vitamin E as a potent antioxidant could improve the age-related haemorheological abnormalities. For this purpose, male Wistar rats at the age of 3 and 24 months were used. The following parameters were evaluated: red blood cell (RBC) deformability, aggregation, plasma viscosity, vitamin E level, total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI), and the following results were obtained. First, aging was associated with a decrease in RBC deformability and increase in RBC aggregation and plasma viscosity. Second, compared with the young group, while plasma TOS levels and OSI were found to be significantly increased in aged rats, there was no significant change in their plasma TAS level. Third, vitamin E administration produced significant improvement in RBC deformability and decrement in TOS and OSI values in aged rats with respect to young and aged control groups. We did not find any significant effect of vitamin E treatment on RBC aggregation in both young and aged rats and finally, we found a significantly lower plasma vitamin E level in aged rats than in young rats. In conclusion, these findings suggest that blood rheology impairs with age and vitamin E has ameliorating effects on age-induced haemorheological abnormalities especially in RBC deformability, probably by reducing the increased oxidative stress in old age. | URI: | https://hdl.handle.net/11499/8794 | ISSN: | 0015-5500 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Vitamin e treatment enhances erythrocyte deformability in aged rats.pdf | 532.92 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
14
checked on Dec 21, 2024
WEB OF SCIENCETM
Citations
14
checked on Dec 20, 2024
Page view(s)
88
checked on Aug 24, 2024
Download(s)
20
checked on Aug 24, 2024
Google ScholarTM
Check
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.