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Title: | Plasma amino-terminal propeptide of C-type natriuretic peptide concentration in normal-weight and obese children | Authors: | Topçu, S. Özhan, Bayram Alkan, A. Akyol, M. Orhon, F.Ş. Başkan, S. Ulukol, B. Şıklar, Zeynep TUFAN ŞATIROĞLU, N.Lale Tufan, A. Çevik |
Keywords: | Amino-terminal propeptide of C-type natriuretic peptide Biomarker C-type natriuretic peptide Growth Obesity Overweight biological marker natriuretic peptide type C amino-terminal pro-C-type natriuretic peptide, human adolescent adult amino terminal sequence anthropometric parameters Article blood analysis body height body mass child childhood obesity enzyme linked immunosorbent assay female growth rate human infant major clinical study male newborn plasma preschool child puberty school child Turkish citizen blood ideal body weight physiology Adolescent Biomarkers Body Mass Index Child Child, Preschool Female Humans Ideal Body Weight Infant Infant, Newborn Male Natriuretic Peptide, C-Type Pediatric Obesity Turkey |
Publisher: | Galenos Yayincilik, | Abstract: | Objective: In studies on the relationship between amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) concentration and height velocity in children, CNP has been implicated as an emerging new growth marker during childhood. It has been reported that besides its well-studied role in growth, plasma CNP levels are reduced in overweight and/or obese adolescents, suggesting CNP as a potential biomarker in childhood obesity. The primary goal of this study was to test this hypothesis in a Turkish population. Methods: Consent was taken from 317 children [ages 0-18 (158 girls, 159 boys)] and their parents. All subjects were physically examined; anthropometric measurements were obtained. Body mass index was calculated. During routine blood work, 1 mL extra blood was taken. Plasma NT-proCNP concentration was measured by enzyme-linked immunosorbent assay. Results: Results confirmed the previously described relationship between plasma NT-proCNP concentration and growth velocity. Plasma NT-proCNP concentration showed a negative correlation with age, weight, and height in children. Gender was not a factor that alters the age-dependent plasma NT-proCNP concentration until puberty. Conclusion: Unlike previous reports, plasma NT-proCNP concentration of overweight/obese children was not significantly lower than that of children with normal weight in age groups analyzed in a Turkish population. Thus, it is too early to conclude that CNP is a potential biomarker in childhood obesity. Further studies are necessary to address this question. © 2017 by Turkish Pediatric Endocrinology and Diabetes Society. | URI: | https://hdl.handle.net/11499/8832 https://doi.org/10.4274/jcrpe.4543 |
ISSN: | 1308-5727 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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