Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8832
Title: Plasma amino-terminal propeptide of C-type natriuretic peptide concentration in normal-weight and obese children
Authors: Topçu, S.
Özhan, Bayram
Alkan, A.
Akyol, M.
Orhon, F.Ş.
Başkan, S.
Ulukol, B.
Şıklar, Zeynep
TUFAN ŞATIROĞLU, N.Lale
Tufan, A. Çevik
Keywords: Amino-terminal propeptide of C-type natriuretic peptide
Biomarker
C-type natriuretic peptide
Growth
Obesity
Overweight
biological marker
natriuretic peptide type C
amino-terminal pro-C-type natriuretic peptide, human
adolescent
adult
amino terminal sequence
anthropometric parameters
Article
blood analysis
body height
body mass
child
childhood obesity
enzyme linked immunosorbent assay
female
growth rate
human
infant
major clinical study
male
newborn
plasma
preschool child
puberty
school child
Turkish citizen
blood
ideal body weight
physiology
Adolescent
Biomarkers
Body Mass Index
Child
Child, Preschool
Female
Humans
Ideal Body Weight
Infant
Infant, Newborn
Male
Natriuretic Peptide, C-Type
Pediatric Obesity
Turkey
Publisher: Galenos Yayincilik,
Abstract: Objective: In studies on the relationship between amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) concentration and height velocity in children, CNP has been implicated as an emerging new growth marker during childhood. It has been reported that besides its well-studied role in growth, plasma CNP levels are reduced in overweight and/or obese adolescents, suggesting CNP as a potential biomarker in childhood obesity. The primary goal of this study was to test this hypothesis in a Turkish population. Methods: Consent was taken from 317 children [ages 0-18 (158 girls, 159 boys)] and their parents. All subjects were physically examined; anthropometric measurements were obtained. Body mass index was calculated. During routine blood work, 1 mL extra blood was taken. Plasma NT-proCNP concentration was measured by enzyme-linked immunosorbent assay. Results: Results confirmed the previously described relationship between plasma NT-proCNP concentration and growth velocity. Plasma NT-proCNP concentration showed a negative correlation with age, weight, and height in children. Gender was not a factor that alters the age-dependent plasma NT-proCNP concentration until puberty. Conclusion: Unlike previous reports, plasma NT-proCNP concentration of overweight/obese children was not significantly lower than that of children with normal weight in age groups analyzed in a Turkish population. Thus, it is too early to conclude that CNP is a potential biomarker in childhood obesity. Further studies are necessary to address this question. © 2017 by Turkish Pediatric Endocrinology and Diabetes Society.
URI: https://hdl.handle.net/11499/8832
https://doi.org/10.4274/jcrpe.4543
ISSN: 1308-5727
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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