Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/8836
Title: | Human TLR gene family members are differentially expressed in patients with urothelial carcinoma of the bladder | Authors: | Sabah-Ozcan, S. Baser, A. Ölçücü, Taha Barış, İkbal Cansu Elmas, Levent Tuncay, Levent Eskicorapci, S. |
Keywords: | Proinflammatory cytokines TLR expression Urine Urothelial carcinoma interleukin 1beta interleukin 6 interleukin 8 messenger RNA toll like receptor toll like receptor 10 toll like receptor 2 toll like receptor 3 toll like receptor 4 toll like receptor 5 toll like receptor 6 toll like receptor 7 autacoid cytokine isoprotein adult aged Article bladder carcinoma bladder injury cancer staging clinical article enzyme linked immunosorbent assay female gene expression human male neoplasm priority journal real time polymerase chain reaction RNA isolation transitional cell carcinoma tumor volume very elderly bladder tumor gene expression profiling gene expression regulation genetics middle aged multigene family urine Aged Aged, 80 and over Carcinoma, Transitional Cell Cytokines Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Inflammation Mediators Male Middle Aged Multigene Family Protein Isoforms Toll-Like Receptors Urinary Bladder Neoplasms |
Publisher: | Elsevier Inc. | Abstract: | Purpose Toll-like receptors (TLRs) have an important role in the activation of both innate and adaptive immunity in response to pathogens and endogenous danger signals from damaged or dying cells. The aim of this study was to determine the relationship between urothelial carcinoma (UC) and TLR expression. Basic procedures Real-time polymerase chain reaction evaluation was made of the messenger RNA expression of TLRs 1–10 in 24 UC samples and 46 nontumoral bladder tissue samples. The levels of proinflammatory cytokines (IL-1ß IL-6, and IL-8) in the urine samples were also determined with enzyme-linked immunosorbent assay. Main findings TLR2–7 and TLR10 expressions were significantly higher in UC than in the control group (P<0.05 for all comparisons). No concordance was found between matched tumor tissue and urine samples in terms of TLR expression. IL-1ß IL-6, and IL-8 levels were significantly higher in urine specimens of patients with UC (P = 0.033, P = 0.001, and P = 0.008, respectively). Principal conclusions The results of this study demonstrated that the TLR gene expression profiles reflect the heterogeneity within UC. These results might also prompt further investigation to better understand the role of the TLR gene family expression in the tumor progression of UC. © 2017 Elsevier Inc. | URI: | https://hdl.handle.net/11499/8836 https://doi.org/10.1016/j.urolonc.2017.07.029 |
ISSN: | 1078-1439 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
SCOPUSTM
Citations
5
checked on Feb 24, 2024
WEB OF SCIENCETM
Citations
3
checked on Aug 1, 2024
Page view(s)
50
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.